Table 1 Patients' characteristics before and after inverse probability weighting
From: Timing of renal replacement therapy initiation by AKIN classification system
Before weighting | After inverse probability of treatment weighting | ||||||
|---|---|---|---|---|---|---|---|
AKI ( n = 150) | ED group ( n = 64) | LD group ( n = 86) | Standardized difference | P -value | Standardized difference | P -value | |
Age, years | 55.5 ± 19.1 | 54.6 ± 19.7 | 56.2 ± 18.4 | 0.08 | 0.604 | 0.09 | 0.586 |
Sex, male, n (%) | 84 (57.5) | 35 (54.7) | 51 (59.3) | 0.09 | 0.539 | 0.01 | 0.960 |
Diabetes mellitus, n (%) | 34 (22.7) | 14 (21.9) | 20 (23.2) | 0.03 | 0.05 | 0.812 | |
Hypertension, n (%) | 67 (44.7) | 27 (42.1) | 40 (46.5) | 0.09 | 0.07 | 0.698 | |
Lower sCr, mg/dL | 0.90 ± 0.30 | 0.96 ± 0.30 | 0.87 ± 0.29 | 0.29 | 0.056 | 0.03 | 0.849 |
Surgical ICU admission, n (%) | 27 (18.0) | 32 (50) | 45 (52.3) | 0.04 | 0.778 | 0.13 | 0.409 |
Sepsis diagnosed, n (%) | 129 (86.0) | 56 (87.5) | 73 (84.9) | 0.07 | 0.648 | 0.13 | 0.402 |
Data at ICU admission | |||||||
Vasoactive drugs, n (%) | 116 (77.3) | 49 (76.6) | 67 (77.9) | 0.03 | 0.846 | 0.15 | 0.338 |
Systolic blood pressure, mmHg | 101.0 ± 22.9 | 91.8 ± 20.2 | 108.6 ± 22.5 | 0.73 | 0.001 | 0.17 | 0.174 |
Diastolic blood pressure, mmHg | 59.4 ± 14.9 | 55.5 ± 13.4 | 62.5 ± 15.3 | 0.13 | 0.033 | 0.14 | 0.201 |
Heart rate, bpm | 101.1 ± 23.5 | 104.7 ± 21.5 | 99.3 ± 24.8 | 0.23 | 0.160 | 0.02 | 0.872 |
Hemoglobin, g/dL | 10.1 ± 2.2 | 9.8 ± 2.4 | 10.5 ± 2.1 | 0.29 | 0.069 | 0.14 | 0.367 |
White blood cells, x103/mm3 | 17.0 ± 8.6 | 15.9 ± 6.6 | 17.5 ± 7.4 | 0.07 | 0.643 | 0.11 | 0.659 |
Platelet count, x103/mm3 | 230.4 ± 121.7 | 235.3 ± 131.2 | 226.4 ± 120.2 | 0.06 | 0.724 | 0.15 | 0.349 |
Creatinine, mg/dL | 2.11 ± 1.22 | 2.0 ± 0.9 | 1.7 ± 0.8 | 0.04 | 0.791 | 0.11 | 0.357 |
Urea, mg/dL | 78.7 ± 43.1 | 82.7 ± 44.1 | 75.4 ± 41.8 | 0.12 | 0.481 | 0.09 | 0.560 |
Potassium, mEq/L | 4.4 ± 2.1 | 4.7 ± 1.4 | 4.2 ± 0.9 | 0.14 | 0.394 | 0.03 | 0.494 |
Bicarbonate, mEq/L | 17.7 ± 5.7 | 16.7 ± 5.5 | 18.5 ± 5.9 | 0.30 | 0.071 | 0.19 | 0.250 |
GCS score | 12.8 ± 2.7 | 12.8 ± 3.1 | 12.8 ± 2.5 | 0.01 | 0.986 | 0.17 | 0.331 |
APACHE II score | 18.8 ± 6.1 | 19.2 ± 6.3 | 18.7 ± 5.9 | 0.08 | 0.520 | 0.03 | 0.848 |
SAPS III score | 61.1 ± 11.9 | 62.1 ± 11.7 | 60.2 ± 12.0 | 0.15 | 0.327 | 0.20 | 0.227 |
Data at RRT start | |||||||
Creatinine, mg/dL | 2.93 ± 1.82 | 2.7 ± 1.1 | 2.8 ± 1.5 | 0.04 | 0.780 | 0.03 | 0.855 |
Urea, mg/dL | 106.7 ± 64.8 | 100.1 ± 54.9 | 108.2 ± 55.6 | 0.17 | 0.461 | 0.02 | 0.908 |
Potassium, mEq/L | 5.3 ± 2.0 | 4.9 ± 1.9 | 5.1 ± 2.1 | 0.11 | 0.499 | 0.15 | 0.392 |
Bicarbonate, mEq/L | 16.2 ± 4.4 | 14.4 ± 3.9 | 17.2 ± 4.3 | 0.64 | < 0.0001 | 0.14 | 0.501 |
APACHE II score | 20.2 ± 6.3 | 20.3 ± 6.8 | 20.1 ± 6.2 | 0.06 | 0.637 | 0.05 | 0.737 |
SAPS III score | 62.6 ± 12.3 | 63.2 ± 11.8 | 62.7 ± 11.6 | 0.10 | 0.469 | 0.14 | 0.298 |
Indications for dialysis | |||||||
Azotemia, n (%) | 27 (18.0) | 7 (10.9) | 20 (23.3) | 0.34 | 0.052 | 0.06 | 0.715 |
Oligoanuria, n (%) | 118 (78.7) | 53 (82.8) | 65 (75.6) | 0.18 | 0.285 | 0.20 | 0.305 |
Metabolic acidosis, n (%) | 96 (64.0) | 46 (71.9) | 50 (58.1) | 0.29 | 0.083 | 0.17 | 0.358 |
Hyperkalemia, n (%) | 21 (14.0) | 4 (6.2) | 17 (19.8) | 0.41 | 0.018 | 0.13 | 0.402 |