Skip to main content

Table 2 Bleeding characteristics and treatments administered to the 15 patients

From: Recombinant factor VIIa for uncontrollable bleeding in patients with extracorporeal membrane oxygenation: report on 15 cases and literature review

Parameter Value
Site of bleeding   
   Venoarterial ECMO   
Mediastinal (post-surgery) 11 (73.3)
   Venovenous ECMO   
Mediastinal (post-surgery) 1
Hemothorax 1
Gynecologic 1
Epistaxis 1
Transfusion required   
   Packed red blood cell 17 (13.5-19)
   Fresh-frozen plasma 14 (9-21.5)
   Concentrated platelets 5 (3-8)
Biologic parameters before and after rFVIIa infusion Before After
   Hemoglobin 7.5 (7.1-8.6) 9 (8.2-9.8)
   Platelets 83 (61-117) 68 (61-106)
   PT 46 (42-52) 101 (54-120)
   aPTT 1.7 (1.4-2.2) 1.4 (1.2-1.9)
   Ionized calcemia 1.10 (1.05-1.20) 1.17 (1.03-1.28)
   pH 7.37 (7.28-7.42) 7.41 (7.34-7.47)
Temperature before rFVIIa infusion (°C) 36.4 (34.3-37.1)
rFVIIa dose infused (μg/kg) 77 (54-144)
Number of injections of rFVIIa, number of patients   
   1 10
   2 3
   3 1
   4 1
  1. Data are expressed as number (%) or medians (IQR). aPTT, activated thromboplastin time; ECMO, extracorporeal membrane oxygenation; PT, prothrombin time; rFVIIA, recombinant factor VIIa.