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Table 3 Multivariate logistic regression analysis of blood markers (natural log-transformed) between favorable and poor outcome groups

From: Predictive value of circulating interleukin-6 and heart-type fatty acid binding protein for three months clinical outcome in acute cerebral infarction: multiple blood markers profiling study

 

OR (95% CI)

P

Adjusted ORa

P

Neuronal markers

    

   NSE

1.23 (0.89 - 1.68)

0.209

0.79 (0.49 - 1.26)

0.325

   Ngb

1.73 (1.28 - 2.34)

0.0004

1.41 (0.89 - 2.24)

0.143

   hFABP

4.90 (2.67 - 9.00)

< 0.0001

3.23 (1.44 - 7.27)

0.0045

   VSNL-1b

1.26 (0.38 - 4.14)

0.704

0.87 (0.19 - 4.02)

0.854

Astroglial markers

    

   S100B

1.60 (1.39 - 1.92)

< 0.0001

1.20 (0.96 - 1.51)

0.115

   GFAPb

2.79 (1.42 - 5.49)

0.003

1.15 (0.41 - 3.22)

0.791

Inflammatory markers

    

   IL-6

2.23 (1.68 - 2.95)

< 0.0001

1.75 (1.25 - 2.25)

0.001

   TNF-α

1.22 (0.94 - 1.57)

0.134

1.35 (0.88 - 2.05)

0.166

   CRP

1.63 (1.33 - 1.99)

< 0.0001

1.23 (0.94 - 1.62)

0.148

Blood-brain barrier marker

    

   MMP-9

2.19 (1.43 - 3.44)

0.005

1.65 (1.07 - 2.07)

0.014

Haemostatic markers

    

   PAI-1

1.05 (0.79 - 1.38)

0.748

1.07 (0.71 - 1.61)

0.751

   D-dimer

2.49 (1.61 - 3.86)

< 0.0001

1.37 (0.74 - 2.57)

0.319

  1. The favorable group is regarded as the reference (OR: 1.0). aAdjustment of age and initial NIHSS score; bcategorical variables. CI, confidence interval; CRP, C-reactive protein; GFAP, glial fibrillary acidic protein; hFABP, heart type fatty acid binding protein; MMP-9 matrix metalloproteinase-9; Ngb, neuroglobin; NSE, neuron-specific enolase; OR, odds ratio; PAI-1, plasminogen activator inhibitor-1; VSNL-1, visinin-like protein 1.