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Table 1 Baseline characteristics for Sapphire study patients.

From: Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury

   Endpoint positive Endpoint negative All patients P values
All patients 101 627 728  
Male   65 (64%) 384 (61%) 449 (62%) 0.58
Age 1   65 (57-77) 64 (52-73) 64 (53-73) 0.048
Race      0.98
  White 81 (80%) 492 (78%) 573 (79%)  
  Black 11 (11%) 76 (12%) 87 (12%)  
  Other/Unknown 9 (9%) 59 (9%) 68 (9%)  
Chronic comorbidities     
  Chronic kidney disease 14 (14%) 51 (8%) 65 (9%) 0.14
  Diabetes mellitus 39 (39%) 171 (27%) 210 (29%) 0.064
  Congestive heart failure 23 (23%) 99 (16%) 122 (17%) 0.17
  Coronary artery disease 33 (33%) 187 (30%) 220 (30%) 0.48
  Hypertension 76 (75%) 357 (57%) 433 (59%) 0.001
  Chronic obstructive pulmonary disease 21 (21%) 141 (22%) 162 (22%) 0.80
  Cancer 25 (25%) 163 (26%) 188 (26%) 0.53
ICU type     0.47
  Medical 40 (40%) 185 (30%) 225 (31%)  
  Surgical 24 (24%) 155 (25%) 179 (25%)  
  Combined ICU 14 (14%) 133 (21%) 147 (20%)  
  Cardiac surgery 6 (6%) 55 (9%) 61 (8%)  
  Neurologic 5 (5%) 34 (5%) 39 (5%)  
  Coronary care unit 5 (5%) 25 (4%) 30 (4%)  
  Trauma 4 (4%) 20 (3%) 24 (3%)  
  Other/Unknown 3 (3%) 20 (3%) 23 (3%)  
Reason for ICU admission 2     
  Respiratory 47 (47%) 263 (42%) 310 (43%) 0.39
  Surgery 32 (32%) 215 (34%) 247 (34%) 0.65
  Cardiovascular 41 (41%) 202 (32%) 243 (33%) 0.11
  Sepsis 26 (26%) 110 (18%) 136 (19%) 0.055
  Neurological 8 (8%) 62 (10%) 70 (10%) 0.72
  Trauma 4 (4%) 51 (8%) 55 (8%) 0.16
  Other 21 (21%) 105 (17%) 126 (17%) 0.32
Enrollment serum creatinine 1,3 1.4 (0.9-1.8) 0.9 (0.7-1.2) 0.9 (0.7-1.2) <0.001
APACHE III 1,4 85 (59-106) 67 (51-88) 69 (51-91) <0.001
  1. Baseline characteristics are shown for all patients in the study and patients that are either negative or positive for the primary study endpoint (KDIGO stage 2 or 3 within 12 hours). 1Median (interquartile range); 2percentages for reason for ICU admission do not sum to 100% because more than one reason can be given; 3value in hospital record closest to enrollment time; 4 calculated from source data by the study sponsor. APACHE III, Acute Physiology and Chronic Health Evaluation III.