Increasing mean arterial blood pressure in sepsis: effects on fluid balance, vasopressor load and renal function

Corrêa, Thiago Domingos; Vuda, Madhusudanarao; Takala, Jukka; Djafarzadeh, Siamak; Silva, Eliézer; Jakob, Stephan Mathias

doi:10.1186/cc12495

Critical Care

Table 3 Inflammatory markers and organ function analysis

From: Increasing mean arterial blood pressure in sepsis: effects on fluid balance, vasopressor load and renal function

Variable	Group	BL	EOP	End	P-value^¶
IL-6,	Septic-CG	24 ± 44	781 ± 410*	1785 ± 819	<0.001^a
pg/mL	Low-MAP	20 ± 26	291 ± 165	57 ± 59^#	0.61^b
	High-MAP	5 ± 10	258 ± 107	95 ± 177
TNF-α,	Septic-CG	102 ± 75	290 ± 145*	410 ± 160	<0.001^a
pg/mL	Low-MAP	48 ± 16	149 ± 55	93 ± 45^#	0.52^b
	High-MAP	57 ± 39	130 ± 89	76 ± 65
Hemoglobin,	Septic-CG	9.4 ± 0.8	15.4 ± 1.6	14.7 ± 1.8	<0.001^a
mg/dL	Low-MAP	9.3 ± 0.6	14.7 ± 0.7	8.4 ± 0.8	0.014^b
	High-MAP	9.2 ± 0.4	14.8 ± 1.2	10.0 ± 1.2	0.008^c
Platelets,	Septic-CG	296 ± 97	131 ± 66*	98 ± 53	0.18^a
x 10⁹/L	Low-MAP	255 ± 48	176 ± 41	115 ± 42^#	0.19^b
	High-MAP	323 ± 102	131 ± 66	98 ± 53
White blood cell count,	Septic-CG	14.0 ± 1.6	9.7 ± 3.0*	10.7 ± 2.8	0.013^a
x 10⁹/L	Low-MAP	18.4 ± 5.2	12.6 ± 4.1	16.9 ± 5.2^#	0.014^b
	High-MAP	16.9 ± 3.5	18.2 ± 5.0	18.9 ± 4.7	0.46^c
Bands,	Septic-CG	2.8 ± 4.1	38.1 ± 8.2*	28.6 ± 19.8	0.021^a
%	Low-MAP	11.6 ± 15.6	57.2 ± 9.6	23.4 ± 18.2^#	0.05^b
	High-MAP	0.8 ± 0.7	63.9 ± 8.6	27.4 ± 10.0	0.59^c
Metamyelocytes,	Septic-CG	0.0 ± 0.0	14.3 ± 12.1*	12.5 ± 7.5	0.001^a
%	Low-MAP	0.0 ± 0.0	6.2 ± 3.3	1.9 ± 3.6^#	0.93^b
	High-MAP	0.0 ± 0.0	6.5 ± 4.1	1.4 ± 3.0
Creatinine,	Septic-CG	0.5 (0.4, 0.8)	1.6 (1.4, 1.6)*	2.3 (2.0, 2.6)	<0.03^d
mg/dl, median (IQR)	Low-MAP	0.9 (0.8, 1.0)	1.2 (1.0, 1.7)	1.4 (1.0, 2.1)^#	0.295^e
	High-MAP	0.9 (0.8, 0.9)	1.1 (0.9, 1.2)	0.9 (0.7, 1.0)	0.001^f
					0.021^g
Total bilirubin,	Septic-CG	1.6 ± 1.2	1.0 ± 0.0*	1.1 ± 0.4	>0.60^d
µmol/L	Low-MAP	1.5 ± 1.1	1.4 ± 1.1	1.6 ± 1.5^#
	High-MAP	1.3 ± 0.5	1.1 ± 0.4	1.4 ± 0.7
Creatine-kinase,	Septic-CG			475 (360, 779)	0.045^f
U/L, median (IQR)	Low-MAP			253 (232, 470)	0.28^g
	High-MAP			211 (183, 332)
Troponin,	Septic-CG			0.015 (0.013, 0.032)	0.091^f
µg/L, median (IQR)	Low-MAP			0.008 (0.05, 0.028)a^#
	High-MAP			0.007 (0.006, 0.02)

Values are mean ± SD or median (IQR) where indicated. BL, baseline; EOP, end of observation period for Low-mean arterial pressure (MAP) and High-MAP groups (12 h after induction of peritonitis); END, end of the experiment (at 48 hours of resuscitation, or before death if earlier); ^#data available for seven animals; *data available for five animals, in one measured after 24 h of PI, and in four after 18 h of PI; ^¶P-value for ^atime-group interaction with repeated measures analysis of variance (ANOVA) including BL, EOP and END for all study groups (septic control (Septic-CG), Low-MAP and High-MAP groups); ^btime-group interaction with repeated measures ANOVA including BL, EOP and END for Low-MAP and High-MAP groups; ^cindependent samples t-test between Low-MAP and High-MAP groups at the END; ^dtime effect within each group (Septic-CG, Low-MAP and High-MAP) separately assessed by the non-parametric Friedman's test and including BL, EOP and END; ^eKruskal-Wallis test at the EOP; ^fKruskal-Wallis test at the End; ^gMann-Whitney U-test between Low-MAP and High-MAP groups at the END.

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