Figure 1

Study design for the low and high mean arterial pressure (MAP) groups. Black circles, samples from the right quadriceps muscle to assess mitochondrial function and quantification of skeletal muscle ATP content; black triangle, first dose of intravenous antibiotic (piperacillin/tazobactam, 2.25 g, 8-hourly); black square, additional tissue samples from the liver for mitochondrial function analysis at the end of the experiment (66 h or before death, if earlier). Animals allocated to the septic control group (Septic-CG) were followed without resuscitation after induction of peritonitis until death. BL, baseline; PI, peritonitis induction; EOP, end of observation period (before starting resuscitation); End, end of the experiment (at 48 hours of resuscitation or before death if earlier.