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Neuroprotective effect of a new synthetic aspirin-decursinol adduct in a rat model of ischemic stroke

Introduction

Stroke is a major cause of death. This study investigated the preventative effect of a new synthetic drug on brain function in experimentally induced ischemic stroke.

Methods

Male Sprague-Dawley rats were administered aspirin (ASA), decursinol (DA) or ASA-DA before and after ischemic insults. Brain and neuronal damage were examined by TTC staining, PEP-CT, NeuN immunohistochemistry and F-J B histofluorescence. Gliosis was also observed by GFAP and iba-1 immunohistochemistry.

Results

Pretreatment with 20 mg/kg, but not 10 mg/kg, of ASA-DA protected against ischemic neuronal death and damage, and its neuroprotective effect was much more pronounced than that of ASA or DA alone. In addition, treatment with 20 mg/kg ASA-DA reduced the ischemia-induced activation of astrocytes and microglia.

Conclusion

Our findings indicate that ASA-DA, a new synthetic drug, prevents against transient focal cerebral ischemia, which provides a resource for the development of its clinical application for stroke.

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Correspondence to YH Lee.

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Lee, Y., Park, C., Cho, J. et al. Neuroprotective effect of a new synthetic aspirin-decursinol adduct in a rat model of ischemic stroke. Crit Care 17, P345 (2013). https://doi.org/10.1186/cc12283

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Keywords

  • Aspirin
  • Adduct
  • Ischemic Stroke
  • Cerebral Ischemia
  • Neuroprotective Effect