Table 1 Pulmonary cytokine and chemokine levels in wild-type (WT) and protease-activated receptor-1 (PAR-1 KO) mice 6, 24 and 48 hours after induction of pneumococcal pneumonia.
| Â | T = 6 | T = 24 | T = 48 | |||
|---|---|---|---|---|---|---|
| Â | WT n = 8 | PAR-1 KO n = 8 | WT n = 8 | PAR-1 KO n = 8 | WT n = 8 | PAR-1 KO n = 8 |
TNF-α (pg/ml) | 4.45 (3.28-7.10) | 5.70 (5.20-7.20) | 10.5 (1.30-24.0) | 13.0 (3.50-56.1) | 27.3 (15.9-40.6) | 175 (43.7-215)** |
IL-6 (pg/ml) | 7.95 (2.50-11.3) | 11.6 (10.0-14.7) | 227 (23.0-1418) | 366 (15.5-1460) | 217 (147-382) | 770 (397-1642)* |
IL-10 (pg/ml) | B.D. | B.D. | 44.3 (34.2-66.6) | 34.7 (30.5-39.3) | 16.9 (10.0-24.8) | 25.1 (16.3-169) |
IFN-γ (pg/ml) | B.D. | B.D. | 11.7 (9.30-17.4) | 13.7 (3.10-34.0) | 4.80 (2.90-8.85) | 16.7 (11.3-23.2)* |
MCP-1 (ng/ml) | 0.15 (0.13-0.29) | 0.19 (0.12-0.28) | 8.38 (4.30-9.93) | 5.28 (2.48-7.28) | 3.29 (2.88-6.34) | 5.69 (2.68-10.1) |
MIP-2 (ng/ml) | B.D. | B.D. | 6.89 (3.81-15.9) | 12.6 (0.20-37.6) | 1.95 (0.77-17.3) | 1.14 (1.01-5.05) |