Table 3 Multivariate model of factors associated with dementia diagnosis during three years of follow-up.
From: Risk factors for dementia after critical illness in elderly medicare beneficiaries
| Â | Multivariable Model | ||
|---|---|---|---|
| Â | Adjusted HR | (95% CI) | P Value |
Index Hospitalization | Â | Â | Â |
No Infection | 1 (ref) | - | - |
Infection onlya | 1.25 | (1.17, 1.35) | < .01 |
Severe sepsis | 1.40 | (1.28, 1.53) | < .01 |
None | 1 (ref) | - | - |
Acute neurologic dysfunctionb | 2.06 | (1.72, 2.46) | < .01 |
No acute RRT | 1 (ref) | - | - |
Acute RRT (post 6 months) | 1.70 | (1.30, 2.23) | < .01 |
Acute RRT (6 months of follow-up) | 0.73 | (0.40, 1.33) | 0.30 |
Surgical | 1 (ref) | - | - |
Medical | 1.41 | (1.33, 1.50) | < .01 |
None | 1 (ref) | - | - |
Any prior hospitalization | 1.36 | (1.27, 1.46) | < .01 |
Age 66 to 69 years | 1 (ref) | - | - |
Age 70 to 74 years | 1.65 | (1.45, 1.87) | < .01 |
Age 75 to 79 years | 2.36 | (2.09, 2.66) | < .01 |
Age 80 to 84 years | 3.74 | (3.33, 4.21) | < .01 |
Age 85+ years | 5.37 | (4.77, 6.05) | < .01 |
Non-hispanic, White | 1 (ref) | - | - |
Other races (hispanic and other) | 1.18 | (1.02, 1.36) | 0.03 |
Non-hispanic, Black | 1.78 | (1.62, 1.97) | < .01 |
Male | 1 (ref) | - | - |
Female | 1.17 | (1.10, 1.24) | < .01 |
Cerebrovascular disease | 1.53 | (1.40, 1.68) | < .01 |
Depression | 1.23 | (1.08, 1.40) | < .01 |
Parkinson's Disease | 2.31 | (1.90, 2.80) | < .01 |
Alcohol Abuse | 1.55 | (1.18, 2.04) | < .01 |
Hypoglycemia (2 years of follow-up) | 1.41 | (1.12, 1.77) | < .01 |
Hypoglycemia (post 2 years of follow-up) | 0.88 | (0.57, 1.36) | 0.56 |
Hypertension (6 months of follow-up) | 1.08 | (0.96, 1.22) | 0.22 |
Hypertension (post 6 months of follow-up) | 0.52 | (0.48, 0.56) | < .01 |
Chronic renal failure (2 years of follow-up) | 1.29 | (1.11, 1.51) | < .01 |
Chronic renal failure (post 2 years of follow-up) | 0.81 | (0.62, 1.06) | 0.12 |