Skip to main content

Table 3 Multivariate model of factors associated with dementia diagnosis during three years of follow-up.

From: Risk factors for dementia after critical illness in elderly medicare beneficiaries

  Multivariable Model
  Adjusted HR (95% CI) P Value
Index Hospitalization    
No Infection 1 (ref) - -
Infection onlya 1.25 (1.17, 1.35) < .01
Severe sepsis 1.40 (1.28, 1.53) < .01
None 1 (ref) - -
Acute neurologic dysfunctionb 2.06 (1.72, 2.46) < .01
No acute RRT 1 (ref) - -
Acute RRT (post 6 months) 1.70 (1.30, 2.23) < .01
Acute RRT (6 months of follow-up) 0.73 (0.40, 1.33) 0.30
Surgical 1 (ref) - -
Medical 1.41 (1.33, 1.50) < .01
None 1 (ref) - -
Any prior hospitalization 1.36 (1.27, 1.46) < .01
Age 66 to 69 years 1 (ref) - -
Age 70 to 74 years 1.65 (1.45, 1.87) < .01
Age 75 to 79 years 2.36 (2.09, 2.66) < .01
Age 80 to 84 years 3.74 (3.33, 4.21) < .01
Age 85+ years 5.37 (4.77, 6.05) < .01
Non-hispanic, White 1 (ref) - -
Other races (hispanic and other) 1.18 (1.02, 1.36) 0.03
Non-hispanic, Black 1.78 (1.62, 1.97) < .01
Male 1 (ref) - -
Female 1.17 (1.10, 1.24) < .01
Cerebrovascular disease 1.53 (1.40, 1.68) < .01
Depression 1.23 (1.08, 1.40) < .01
Parkinson's Disease 2.31 (1.90, 2.80) < .01
Alcohol Abuse 1.55 (1.18, 2.04) < .01
Hypoglycemia (2 years of follow-up) 1.41 (1.12, 1.77) < .01
Hypoglycemia (post 2 years of follow-up) 0.88 (0.57, 1.36) 0.56
Hypertension (6 months of follow-up) 1.08 (0.96, 1.22) 0.22
Hypertension (post 6 months of follow-up) 0.52 (0.48, 0.56) < .01
Chronic renal failure (2 years of follow-up) 1.29 (1.11, 1.51) < .01
Chronic renal failure (post 2 years of follow-up) 0.81 (0.62, 1.06) 0.12
  1. aBacterial or fungal infection but without acute organ failure (that is, no diagnosis of severe sepsis); bacute neurologic dysfunction includes delirium, anoxia, and encephalopathy. Extended Cox-model adjusted for risk factors of dementia and time dependent coefficients, see online data supplement for full model, global null hypothesis likelihood ratio test P < .0001. HR, hazard ratio; ref, reference; RRT, renal replacement therapy.