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Table 2 Frequency of dementia diagnoses in three years of follow-up by characteristics from the index hospitalization.

From: Risk factors for dementia after critical illness in elderly medicare beneficiaries

  Total Cohort, number Dementia in 3 years follow-up, number (%) HR (95% CI) P Value
Total cohort 25,368 4,519 (17.8)    
   Surgical 12,740 1,780 (14.0) 1 (ref) - -
   Medical 12,628 2,739 (21.7) 1.75 (1.65, 1.85) < .01
Mechanical Ventilation      
   None 23,067 4,108 (17.8) 1 (ref) - -
   < 96 hours 1,716 301 (17.5) 1.09 (0.97, 1.22) 0.17
   ≥ 96 hours 585 110 (18.8) 1.25 (1.05, 1.49) 0.01
No Acute RRT 25,094 4,453 (17.8) - - -
Acute RRT 274 66 (24.1) 1.61 (1.26, 2.05) < .01
No Infection 17,151 2,783 (16.2) 1 (ref) - -
Infection onlya 5,072 1,053 (20.8) 1.44 (1.34, 1.54) < .01
Severe sepsis 3,145 683 (21.7) 1.63 (1.50, 1.77) < .01
Acute Organ Dysfunction      
None 19,165 3,289 (17.2) 1 (ref) - -
One 5,003 973 (19.5) 1.25 (1.16, 1.34) < .01
Two or more 1,200 257 (21.4) 1.43 (1.26, 1.62) < .01
   Specific Organ Dysfunctionb      
Cardiac 1,888 351 (18.6) 1.08 (0.97, 1.20) 0.18
Respiratory 2,164 394 (18.2) 1.17 (1.05, 1.30) < .01
Renal 2,194 464 (21.2) 1.37 (1.24, 1.51) < .01
Neurologic 351 130 (37.0) 2.38 (2.00, 2.84) < .01
Encephalopathy 144 53 (36.8) - - -
Delirium 167 68 (40.7) - - -
Anoxia 48 12 (27.1) - - -
Hematologic 940 176 (18.7) 1.12 (0.96, 1.30) 0.14
ICU length of stay (quartiles)c      
1 8,255 1,290 (15.6) 1 (ref) - -
2 5,349 977 (18.3) 1.23 (1.13, 1.34) .04
3 6,748 1,270 (18.8) 1.31 (1.21, 1.41) .11
4 4,953 971 (19.6) 1.44 (1.33, 1.57) < .01
Hospital length of stay (quartiles)d      
1 7,201 1,068 (14.7) 1 (ref) - -
2 6,848 1,218 (17.8) 1.30 (1.20, 1.41) < .01
3 5,640 1,085 (19.2) 1.47 (1.35, 1.60) < .01
4 5,679 1,156 (20.4) 1.70 (1.56, 1.84) < .01
  1. aBacterial or fungal infection but without acute organ failure (that is, no diagnosis of severe sepsis); bhepatic failure, as a subtype of acute organ dysfunction, is not shown because of low frequency. The reference group for each of the five subtypes is everyone without that dysfunction; cmissing data on 63 patients; dhospital length of stay includes ICU days. HR, hazard ratio; ref, reference; RRT, renal replacement therapy.