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Figure 1 | Critical Care

Figure 1

From: Effects of the neurological wake-up test on clinical examination, intracranial pressure, brain metabolism and brain tissue oxygenation in severely brain-injured patients

Figure 1

Clinical and hemodynamic changes during is-trials. Panel A shows median increase of GCS (empty circle) and the Four score (filled circle) during the IS-trial. Panel B-F gives average time course of cardiopulmonary, cerebrovascular parameters and ICP (y-axis) at baseline (time = 0) during the trial (grey square) and over 2 hours following restart of sedation and analgesics (x-axis) in patients where the trial was completed (empty square) and aborted (filled square). P-value is given for significant differences of time points (Panel A) or differences of parameters over time (Panel B-F) (** = P < 0.001, * = P < 0.05). On Panel B-F error bars represent means and one standard error of n = 54 individual trials. CPP, cerebral perfusion pressure; HR, heart rate; ICP, intracranial pressure; MAP, mean arterial pressure; RR, respiratory rate.

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