Table 4 Impedance aggregometry findings, sepsis markers, ICU-scores, and coagulation variables, in survivors and non-survivors of severe sepsis
From: Whole blood impedance aggregometry as a biomarker for the diagnosis and prognosis of severe sepsis
Testnormal range | Survivorsmean and SEM median (quartiles) | Non-survivorsmean and SEM median (quartiles) | Significance level Mann-Whitney test |
|---|---|---|---|
Aggregometry | |||
ADP-test 53 - 122 AU | 37.35 ± 4.39 32.30 (9.33, 48.98) | 15.03 ± 3.03 9.65 (4.45, 22.43) | 0.004 |
AA-test 74 - 136 AU | 59.82 ± 5.75 43.45 (22.35, 93.85) | 39.15 ± 7.71 25.50 (10.03, 60.75) | 0.059 |
Col-test 46 - 116 AU | 40.89 ± 4.29 33.40 (10.90, 48.78) | 18.43 ± 3.79 12.40 (6.50, 24.95) | 0.001 |
TRAP-test 94 - 156 AU | 66.76 ± 5.09 54.75 (33.20, 97.08) | 32.50 ± 5.59 24.45 (13.20, 56.33) | <0.001 |
Sepsis marker | |||
Procalcitonin 0 - 0.5 ng/ml | 17.74 ± 6.22 3.39 (1.14, 17.35) | 22.28 ± 8.79 5.56, (3.16, 17.83) | 0.091 |
IL 6 0 - 3.4 pg/ml | 172.53 ± 32.81 77.5 (32.20, 160.75) | 2638.10 ± 1162 533.0 (72.4, 2059) | 0.001 |
CRP 0 - 0.5 mg/dl | 13.74 ± 1.21 12.85 (6.13, 18.68) | 13.94 ± 1.93 13.65 (6.20, 18.15) | 0.833 |
ICU scores | |||
SAPSII | 47.2 ± 10.6 49.0 (32.0, 65.0) | 54.2 ± 12.3 (n.s.) 55.0 (43.8, 64.7) | 0.167 |
SOFA | 10.6 ± 4.6 11.0 (7.0, 14.0) | 14.6 ± 3.6 14.5 (12.0, 16.8) | 0.001 |
Coagulation variables | |||
INR 0.89 - 1.11 | 1.31 ± 0.06 1.19 (1.11, 1.40) | 1.64 ± 0.14 1.49 (1.24, 1.94) | 0.006 |
Thrombin time | 24.0 ± 2.0 | 23.4 ± 3.2 | |
14 - 21 s | 19.0 (15.0, 25.1) | 17.4 (16.1, 27.5) | 0.955 |
Fibrinogen | 498 ± 33 | 414 ± 63 | |
210 - 400 mg/dl | 512 (251, 676) | 323 (231, 662) | 0.159 |
Platelets | 154 ± 14 | 72 ± 11 | |
160 - 350/nl | 131 (72, 224) | 65 (44, 95) | <0.001 |