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Table 3 Subgroup analysis and meta-regression of studies assessing the efficacy of intensive glycemic control in neurocritical care patients

From: Optimal glycemic control in neurocritical care patients: a systematic review and meta-analysis

Comparison Mortality Poor neurological outcome
  Studies, number Risk ratio (95% confidence intervals) P -value for comparison Studies, number Risk ratio (95% confidence intervals) P -value for comparison
Control group       
Very loose 10 0.98 (0.80-1.20)   8 0.88 (0.79-0.98)  
Moderate 6 1.00 (0.72-1.39) 0.89 5 0.99 (0.85-1.14) 0.04
Hypoglycemia†       
Uncommon 7 1.00 (0.86-1.24)   5 0.94 (0.84-1.06)  
Common 6 1.17 (0.78-1.76) 0.72 6 0.94 (0.81-1.08) 0.94
Duration of tight control       
> 72 hours 12 0.99 (0.83-1.18)   11 0.92 (0.84-1.01)  
< 72 hours 4 0.97 (0.56-1.67) 0.37 2 0.81 (0.57-1.15) 0.04
Risk of bias       
Higher 11 1.03 (0.86-1.24)   10 0.94 (0.85-1.04)  
Lower 4 1.00 (0.52-1.91) 0.76 3 0.94 (0.76-1.17) 0.17
Timing of nutrition       
As soon as possible 6 1.07 (0.73-1.57)   5 0.93 (0.80-1.08)  
Deferred > 24 hours 5 1.01 (0.81-1.26) 0.82 4 0.90 (0.79-1.03) 0.79
Definition       
Hypoglycemia 8 0.94 (0.67-1.31)   8 0.88 (0.77-1.00)  
56-80 mg/dl
55 mg/dl or below
6 1.01 (0.82-1.23) 0.72 4 0.91 (0.79-1.03) 0.72
  1. As per a priori plan, patients were dichotomized based on the median prevalence of hypoglycemia across studies; common, hypoglycemia occurred in 33-100% of patients; uncommon, hypoglycemia occurred in 3 to 18% of patients.