Table 1 Comparison of outcome data from two multicenter RCTs and patients with severe sepsis

From: CRYSTMAS study adds to concerns about renal safety and increased mortality in sepsis patients

	CRYSTMAS			VISEP[3]
	Percentage 6% HES 130 (n/N)	Percentage crystalloid (n/N)	P -value	Percentage 10% HES 200 (n/N)	Percentage crystalloid (n/N)	P -value
New need for RRT
7-day	17 patients^a	8 patients^a
28-day				31 (81/261)	18.8 (51/272)	0.001
90-day	21 patients^a	11 patients^a
ARF
28-day				34.9 (91/261)	22.8 (62/272)	0.002
90-day	24.5 (24/98)^b	20 (19/95)^b	0.45
Mortality
28-day	31.0 (31/100)^c	25.3% (24/95)^c	0.37	26.7 (70/262)	24.1 (66/274)	0.48
90-day	40.4 (40/99)^c	33.6 (32/95)^c	0.33	33.9 (93/274)	41.0 (107/261)	0.09

^aData according to [4]; total number of patients with available data is not given. ^bData according to [1, 6]. ^cData according to [1]. n = number of patients with condition; N = total number of patients with available data. ARF, acute renal failure; RRT, renal replacement therapy.

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