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Table 1 Characteristics of patients with bleeding (n = 686)

From: Reversal of Vitamin K Antagonist (VKA) effect in patients with severe bleeding: a French multicenter observational study (Optiplex) assessing the use of Prothrombin Complex Concentrate (PCC) in current clinical practice

Demographic data  
   Age in years, mean ± SD 77.8 ± 10.8
   Men, number (percentage) 368 (53.7)
   Weight in kilograms, mean ± SD 72.0 ± 16.2
VKA indicationa, number (percentage)  
   Non-valvular atrial fibrillation 449 (65.5)
   Venous thromboembolic disease 131 (19.1)
   Mechanical heart valve 47 (6.9)
   Not available 89 (13.0)
Other anticoagulant treatmentb, number (percentage)  
   Antiplatelet drugs 143 (22)
Outpatient bleeding risk index: Beyth score, number (percentage)  
   Mild risk 41 (6.0)
   Intermediate risk 586 (85.4)
   High risk 59 (8.6)
Criteria of severe bleedings (n = 646), number (percentage)  
   Life-threatening bleeding or organ-compromising bleeding 574 (88.3)
   Hemodynamic instability 147 (21.4)
   External bleeding uncontrolled with conventional measures 167 (26.3)
   Need for red cell transfusion 217 (31.6)
   Need for urgent surgery 162 (23.6)
  1. aMore than one indication was possible; 89 values were missing; b36 values were missing. Outpatient bleeding risk index was calculated according to Beyth score [29]. Hemodynamic instability was defined as the presence of one or more of the following criteria: systolic blood pressure (SBP) of less than 90 mm Hg, SBP decrease of at least 40 mm Hg, mean blood pressure of less than 65 mm Hg, or any signs of shock. SD, standard deviation; VKA, vitamin K antagonist.