Figure 4
From: Therapeutic efficacy of CXCR3 blockade in an experimental model of severe sepsis
Effect of anti-CXCR3 IgG treatment on cytokine production. Mice were treated with anti-CXC chemokine receptor 3 (anti-CXCR3) IgG (100 µg) or nonspecific IgG (100 µg) 24 hours prior to (n = 10 mice per group), 2 hours after (n = 10 mice per group) or 6 hours after (n = 13 mice per group) cecal ligation and puncture (CLP). Plasma and peritoneal lavage fluid were harvested 18 hours after CLP for measurement of IL-6 and macrophage inflammatory protein 2 (MIP-2) concentrations by ELISA. *P <0.05 compared with nonspecific IgG.