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Multiorgan failure in malaria: what we have learned over the past 10 years

Objectives

Incidence and outcome of multiorgan failure in Severe Malaria. Usefulness of severity of disease scoring systems.

Design and methods

This is a retrospective analysis of data from 152 patients admitted to the Intensive Care Unit at the Chris Hani Baragwanath Hospital between 1990 and 1999 with a confirmed diagnosis of Severe Malaria.

Results

Of the 152 patients, 81 (53.3%) were male and 71 (46.7%) female. The overall mortality was 31.6% (48/152).

Conclusions

The occurrence of acute renal failure in malaria is an ominous event even when it occurs on its own. ARDS is however a serious complication which carries a high mortality. The combination of ARF together with ARDS has an almost universally fatal outcome. APACHE II score, SOFA score and WHO criteria correlate closely with outcome.

Table 1 Demographics
Table 2 Organ failure: incidence and outcome

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Zeippen, B., Joubert, I. & O'Reilly, C. Multiorgan failure in malaria: what we have learned over the past 10 years. Crit Care 5, P096 (2001). https://doi.org/10.1186/cc1163

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Keywords

  • Public Health
  • Intensive Care Unit
  • Renal Failure
  • Malaria
  • High Mortality