Figure 1

12/15-lipoxygenase is involved in LPS-induced pulmonary inflammation. Neutrophil recruitment into the interstitial (A) and BAL (B) compartments of the lung and the wet/dry ratio (C) of WT mice and Alox15^-/- mice with (white bars) or without (black bars) LPS inhalation (24 h) was measured by flow cytometry (n = 3 to 4). Exemplary histological images of lungs from WT mice and Alox15^-/- mice under baseline conditions and after LPS exposure (D-G). Bar indicates 50 µm. ^#P < 0.05, *P < 0.05 versus WT LPS.