Table 3 Positive predictive value (PPV) and negative predictive value (NPV) for assessing the prognostic utility of the baseline values of cfDNA and other variables
From: Prognostic utility and characterization of cell-free DNA in patients with severe sepsis
Variable | Positive predictive value | 95% CI | Likelihood ratio χ2 | Negative predictive value | 95% CI | Likelihood ratio χ2 |
|---|---|---|---|---|---|---|
cfDNA | 0.91 | 0.81-1.00 | 25.64 | 0.91 | 0.83-1.00 | 37.80 |
APACHE II | 0.55 | 0.42-0.69 | 0.64 | 0.88 | 0.74-1.00 | 15.19 |
MODS | 0.65 | 0.45-0.85 | 2.16 | 0.67 | 0.54-0.79 | 6.46 |
Age | 0.53 | 0.39-0.68 | 0.19 | 0.73 | 0.57-0.88 | 7.07 |
TAT complexes | 0.59 | 0.40-0.77 | 0.87 | 0.65 | 0.52-0.79 | 4.67 |
Protein C | 0.64 | 0.43-0.84 | 1.66 | 0.66 | 0.53-0.78 | 5.68 |
IL-6 | 0.86 | 0.59-1.00 | 3.96 | 0.61 | 0.50-0.73 | 3.59 |
Female gender | 0.44 | 0.30-0.57 | 0.89 | 0.60 | 0.40-0.80 | 1.01 |