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Table 3 Side effects of manual hyperinflation (MH)

From: Benefits and risks of manual hyperinflation in intubated and mechanically ventilated intensive care unit patients: a systematic review

Author [ref]

Year

Subjects

N

Study design

Intervention

Reported aspects of the MH maneuver

Main results

Singer et al. [8]

1994

Unselected intensive care unit patients

18

Prospective observational study

Measurements of hemodynamic parameters before and after MH

Volume: +

Inspiration speed:-

Pause: -

Expiration speed: -

MH decreased cardiac output; MH did not affect heart rate or systemic blood pressure

Jellema et al. [32]

2000

Patients with septic shock

13

Prospective observational study

Measurements of hemodynamic parameters before and after MH

Volume: ±

Inspiration speed: -

Pause: +

Expiration speed: +

MH did not affect cardiac output, heart rate, systemic blood pressure, or central venous pressure

Paratz et al. [33]

2002

Patients with ALI

16

Prospective observational study

Measurements of hemodynamic and respiratory parameters before and after MH

Volume: +

Inspiration speed: +

Pause: +

Expiration speed: +

MH did not affect cardiac output, heart rate, systemic blood pressure, or central venous pressure

Paratz et al. [7]

2006

Patients in shock

7

Prospective observational study

Measurements of hemodynamic parameters and plasma catecholamines before and after MH

Volume: +

Inspiration speed: +

Pause: +

Expiration speed: +

MH decreased cardiac output, and increased systemic vascular resistance, and diastolic blood pressure

Hodgson et al. [26]

2000

Unselected intensive care unit patients

18

Randomized crossover trial

MH + endotracheal suction vs. standard care

Volume: -

Inspiration speed: -

Pause: +

Expiration speed: ±

MH did not affect heart rate or systemic blood pressure

Barker et al. [20]

2002

Patients with ALI

18

Randomized controlled trial

MH + endotracheal suction vs. position changes of patient

Volume: +

Inspiration speed: -

Pause : +

Expiration speed: -

MH increased heart rate and systemic blood pressure; MH did not affect pulmonary artery wedge pressure

Paulus et al. [34]

2010

Unselected intensive care unit patients

74

Prospective observational study

Measurements of hemodynamic parameters before and after MH

Volume: +

Inspiration speed: +

Pause: +

Expiration speed: +

MH did not affect systemic blood pressure or peripheral oxygen saturation; MH increased heart rate and end-tidal CO2 levels

Patman et al. [35]

1998

Postcardiac surgery patients

30

Prospective observational study

Measurements of hemodynamic parameters before and after MH

Volume: -

Inspiration speed: -

Pause: ±

Expiration speed: -

MH increased central venous pressures and decreased heart rate; MH did not affect cardiac output

  1. Reported aspects of the MH maneuver: volume, whether larger than normal breaths were used; inspiration speed, whether a low inspiratory flow was used; pause, whether pauses were used; expiration speed, whether rapid expiratory flow was used (+, mentioned; -, not mentioned; ±, uncertain).