Overview of selected tSNPs within the entire RAGE gene. (A) The pair-wise analysis of linkage disequilibrium (LD), based on r2, among the 10 SNPs with a minor allele frequency ³5% within the RAGE gene and 505 bp up- and 5,000 bp down-stream regions. The selected tSNPs are indicated by trigones. A LD-plot of the 10 SNPs is displayed by using r2-black and white color scheme. Black represents very high LD (r2 = 0.8-1), and white indicates the absence of correlation (r2 = 0-0.2) between SNPs. (B) The two tSNPs and SNPs that are indirectly measured by them are listed with corresponding r2-values. Major and minor alleles of the selected tSNPs are given with their frequencies, based on the HapMap data for the CHB population.