|
Covariate
|
HR (95% CI)
|
P
|
|---|
|
Demographic data
|
|---|
|
organ transplantation
|
0.29 (0.09, 0.98)
|
0.05
|
|
age
|
1.04 (1.02, 1.05)
|
< 0.001
|
|
ICU admission and surgery
|
|
CPR*ECMO*
|
0.17 (0.03, 0.99)
|
0.048
|
|
MAP at the peak of AKI
|
0.99 (0.97, 1.00)
|
0.006
|
|
general surgical services
|
1.77 (1.19, 2.64)
|
0.005
|
|
receive CPR
|
6.55 (2.34, 18.32)
|
< 0.001
|
|
Time-dependent variables during follow-up*†
|
|
preserved eGFR during follow-up
|
1
|
reference
|
|
baseline eGFR*CKD3-TD
|
1.007 (1.001, 1.012)
|
0.016
|
|
baseline eGFR*CKD4-TD
|
1.016 (1.010, 1.021)
|
< 0.001
|
|
baseline eGFR*CKD5-TD
|
1.017 (1.008, 1.026)
|
< 0.001
|
|
baseline eGFR*ESRD-TD
|
1.054 (0.959, 1.158)
|
0.3
|
- AKI, acute kidney injury; CI, confidence interval; CKD, chronic kidney disease; CPR, cardiopulmonary resuscitation; ECMO, extracorporeal membrane oxygenation; eGFR, estimated glomerular filtration rate; ESRD, end-stage renal disease; HR, hazard ratio; MAP, mean arterial pressure. *CPR*ECMO indicates the interaction term of receiving both CPR and ECMO; Baseline eGFR*CKD3 (4, 5)-TD indicates the interaction term of baseline eGFR and stage 3 (4, 5) CKD time-dependent variables; Baseline eGFR*ESRD-TD indicates the interaction term of baseline eGFR and ESRD. † The main CKD3, 4, 5-TD factors were not significant in the final model.
