Skip to main content

Table 4 Metabolic and hormonal measurements on ACTH test day

From: Steroidogenesis in the adrenal dysfunction of critical illness: impact of etomidate

  Sepsis Nonsepsis P
  Etomidate No etomidate Etomidate No etomidate  
  n = 11 n = 32 n = 3 n = 21 S, E, E*S
ACTH, pM 1.4 (3.1) 2.4 (2.6) 1.9 (7.5) 4.1 (3.9) 0.37, 0.10, 0.22
Cholesterol, mM 1.3 (0.8) 1.8 (1.2) 2.4 (1.8) 2.8 (1.0) < 0.001, 0.02, 0.75
HDL-cholesterol, mM 0.40 (0.40) 0.60 (0.60) 0.80 (0.80) 0.90 (0.60) 0.06, 0.18, 0.17
Progesterone, nM 0.40 (0.90) 0.50 (0.70) 1.0 (1.0) 0.60 (0.70) 0.55, 0.34, 0.16
Corticosterone, nM 3.4 (4.9) 3.5 (6.4) 5.3 (4.6) 4.0 (7.4) 0.23, 0.04, 0.64
Aldosterone, nM 1.3 (1.3) 0.70 (1.3) 0.50 (0.1) 1.2 (0.7) 0.08, 0.13, 0.007
17-OH-progesterone, nM 2.9 (2.8) 2.6 (1.5) 3.9 (2.1) 2.5 (2.4) 0.48, 0.09, < 0.001
11ß-deoxycortisol, nM 15 (58) 3.1 (8.3) 34 (30) 3.7 (3.3) 0.003, < 0.001, < 0.001
Cortisol, nM 460 (200) 500 (221) 325 (134) 455 (335) 0.03, 0.98, 0.04
Cortisol/11ß-deoxycortiso l26 (175) 157 (352) 12 (28) 316 (380) 0.04, < 0.001, < 0.001
Cortisol/ACTH 209 (340) 223 (229) 171 (270) 109 (80) 0.07, 0.08, 0.08
Cortisol increase, nM 220 (190) 298 (315) 165 (169) 395 (238) 0.04, < 0.001, 0.98
Cortisol increase < 250 nM 6 (54) 14 (44) 2 (67) 6 (29) 0.92, 0.17, 0.43
DHEA, μM 6.1 (4.6) 6.4 (4.9) 6.1 (1.8) 5.9 (4.1) 0.61, 0.61, 0.44
DHEAS, nM 0.70 (1.4) 0.48 (0.76) 0.50 (4.2) 0.90 (1.1) 0.39, 0.03, 0.87
Androstenedione, nM 3.8 (8.6) 2.4 (2.9) 3.6 (2.8) 2.8 (2.4) 0.13, 0.02, 0.60
  1. Median (interquartile range) or number (%). ACTH, adrenocorticotropic hormone; CBG, cortisol-binding globulin; DHEA(S), dihydroxyepiandrostenedione (sulfate). S, sepsis; E, etomidate; E*S, interaction between etomidate and sepsis in generalized estimating equations; HDL, high-density lipoprotein.