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Table 2 Circuit lifetime, CRRT stopping causes and prescribed versus delivered dialysis dose according to different anticoagulation modalities.

From: Regional citrate anticoagulation in cardiac surgery patients at high risk of bleeding: a continuous veno-venous hemofiltration protocol with a low concentration citrate solution

  RCA (n= 152) Heparin (n= 73) No AC (n= 77)
CIRCUIT LIFETIME    
Mean ± SD (hours) 49.8 ± 35.4*** 30.6 ± 24.3 25.7 ± 21.2
Median (hours) 41 22 20
   > 24 hours 74% 45% 40%
   > 48 hours 41% 25% 14%
   > 72 hours 27% 12% 5%
CRRT STOPPING CAUSES    
CVC malfunction 34.9% 17.8% 15.6%
Alarm handling/technical issues 23.7% 12.3% 2.6%
Scheduled 19.7% 0% 1.3%
Medical procedures 13.8% 2.8% 3.9%
Clotting 0% 61.6% 68.8%
Unidentified 7.9% 5.5% 7.8%
DIALYSIS DOSE a    
Prescribed dose (ml/kg/hour) 26.8 ± 3.8 27.3 ± 4.7 26.6 ± 7.1
Delivered dose (ml/kg/hour) 25.6 ± 4.9** 23.7 ± 7.2 23.1 ± 8
Delta dose (%) 4.7 ± 12.1*** 13 ± 20.5 12.7 ± 19.1
  1. Data are expressed as mean ± SD or percentage. aCorrected for predilution. Statistical comparison among different anticoagulation modalities: ANOVA with Bonferroni post-hoc test. ***P < 0.0001; **P < 0.02. AC, anticoagulation; ANOVA, analysis of variance; CRRT, continuous renal replacement therapy; CVC, central venous catheter; n, number; RCA, regional citrate anticoagulation; SD, standard deviation.