Figure 3
From: Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs
Mitochondrial changes following metformin intoxication. Ten pigs were infused with metformin (black bars) and five pigs were not (white dotted bars). Activities of complex I (CI) (A), complex II and III (CII+III) (B) complex IV (CIV) (C) and citrate synthase (CS) (D) were measured at the end of study in heart, kidney, liver, skeletal muscle and platelets. Data are reported as mean and SD. °P = 0.05 vs. saline. *P < 0.05 vs. saline. Platelet mitochondrial function was only measured in seven of the intoxicated pigs.