Figure 1
From: Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs
Major metabolic changes during metformin infusion. Ten pigs were infused with metformin (black bars) and five pigs were not (white dotted bars). Infusion of metformin started after baseline recordings (time 0) and lasted 2.5 to 5 hours (dose infused ranged between 4 and 8 g). Arterial pH (A), lactatemia (B), glycemia (C), global oxygen (O2) delivery (D), consumption (E) and extraction (F) were recorded every hour. Data are reported as mean and SD. *P < 0.05 vs. time 0 within group. To convert glucose in mmol/L, divide by 18.