Table 2 Future research questions in vitamin D and sepsis

Vitamin D and the burden of sepsis in the community

   • What serum 25(OH)D concentration is optimal for immune function?

   • Can vitamin D supplementation reduce the incidence of infection and progression to sepsis?

   • Is vitamin D a causal factor of racial health disparities in sepsis?

   • Is vitamin D a causal factor of the seasonal variations in infection and sepsis?

Vitamin D in the health-care setting

   • Is serum 25(OH)D concentration a reliable measure of vitamin D in critical illness?

   • Can acute vitamin D repletion alter the progression of sepsis and severity of organ dysfunction?

   • Can vitamin D repletion reduce the incidence of hospital-acquired infections?

   • What is a safe dosing schedule for rapid vitamin D repletion and maintenance therapy in hospitalized patients?