|
Parameter
|
Placebo
|
Inhaled NO
|
P Value
|
|---|
|
Age, years
|
N
|
41
|
51
| |
| |
Mean ± SD
|
47.8 ± 16.7
|
45.3 ± 15.3
|
0.494
|
| |
Range
|
18.4 - 84.0
|
16.8 - 77.9
| |
|
Sex, n (%)
|
Male
|
19 (46%)
|
25 (49%)
|
0.836
|
| |
Female
|
22 (54%)
|
26 (51%)
| |
|
Race, n (%)
|
Caucasian
|
35 (85%)
|
42 (82%)
|
0.847
|
| |
Black
|
4 (10%)
|
5 (10%)
| |
| |
Other
|
2 (5%)
|
4 (8%)
| |
|
Height, cm
|
N
|
39
|
51
| |
| |
Mean ± SD
|
168.7 ± 11.4
|
169.4 ± 9.2
|
0.912
|
|
Weight, kg
|
N
|
41
|
51
| |
| |
Mean ± SD
|
85.7 ± 24.1
|
76.4 ± 19.2
|
0.049
|
|
BW ≥ 35% IBW
|
N
|
19 (46.3%)
|
13 (25.5%)
|
0.028
|
|
Causes of ARDS,a n (%)
| | | | |
|
Pneumonia
| |
20 (49%)
|
15 (29%)
|
0.084
|
|
Toxic gas inhalation
| |
0 (0%)
|
0 (0%)
|
1.000
|
|
Acute pancreatitis
| |
1 (2%)
|
3 (6%)
|
0.626
|
|
Massive blood transfusion
| |
5 (12%)
|
10 (20%)
|
0.404
|
|
Fat emboli
| |
1 (2%)
|
2 (4%)
|
1.000
|
|
Aspiration pneumonitis
| |
9 (22%)
|
9 (18%)
|
0.610
|
|
Pulmonary contusion
| |
6 (15%)
|
12 (24%)
|
0.307
|
|
Postpartum ARDS
| |
2 (5%)
|
0 (0%)
|
0.196
|
|
Multiple trauma
| |
14 (34%)
|
15 (29%)
|
0.657
|
|
Elective or emergency surgical procedures
| |
9 (22%)
|
20 (39%)
|
0.114
|
|
Patient History, n (%)
| | | | |
|
Preexisting steroid use
| |
3 (7%)
|
8 (15%)
|
0.334
|
|
Asthma
| |
4 (10%)
|
5 (10%)
|
1.000
|
|
COPD
| |
6 (15%)
|
6 (12%)
|
0.761
|
|
Tobacco use
| |
17 (41%)
|
26 (51%)
|
0.405
|
- aPatients may have more than one cause of ARDS. ARDS, acute respiratory distress syndrome; BW, body weight; COPD, chronic obstructive pulmonary disorder; IBW, ideal body weight; N, number; NO, nitric oxide.
