Figure 3

Histological image of the Control and AAP Group: Lung, Heart, Liver and Kidney (Hematoxylin-eosin). 1 a.) Control lung: I. 25x; normal lung tissue; II. 100x; normal lung tissue 1 b.) AAP lung: I: bronchiolus with neutrophilic granulocytes and foamy macrophages (←); II: acute congestion/stasis of the lung with intraalveolar exudation and hyaline membranes (←) (shock lung); III: pulmonary thrombembolism (←); IV: interstitial edema with fibrinoid and hemorrhagic exudation + neutophilic granulocytes, lost of alveolar structures (←). 2 a.) Control heart: I. 25x. I.) left ventricle: normal cardiomyocytes; II. 100x. I.) left ventricle: normal cardiomyocytes. 2 b.) AAP heart: I left ventricle: increased number of inflammatory cells, spreading from the vessels to cardiac tissue (→); II: impulse conduction system, lymphocytes, macrophages; spreading from the impulse conduction system to the heart muscle cells (→); III: apoptosis of a cardiomyocyte (←, →); IV: inflammatory cells, cell damage in the center of the image (←, →). 3 a.) Control liver: I. 25x; Liver: normal liver lobe with regular septum and central vein II. 100x; normal liver lobe with regular septum and central vein. 3 b.) AAP liver: I: septal region of a portal tract with massive infiltrates of neu-trophilic and eosinophilic granulocytes (←); II: inflammatory cells (←), intracellular edema with swollen hepatocytes (← -), III: inflammatory infiltration in the center (←); IV: central region with cell apoptosis/necrosis and inflammatory cells (←). 4 a.) Control kidney: I., 25x; regular cortical kidney tissue with a glomerulus in the middle of the image; II. He-matoxylin-eosin, 100x; regular cortical kidney tissue with a glomerulus in the middle of the image. 4 b.) AAP kidney: I: disseminated inflammatory cells (←), intracellular edema in tubular epithelial cells (← -), II: cluster of inflammatory cells (←), slight interstitial edema; III: granulocytes (←); necrotic tubular epithelial cells (← -); IV: circle: massive intracellular edema.