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Table 1 The bundle of 10 recommendations

From: Fluid management and risk factors for renal dysfunction in patients with severe sepsis and/or septic shock

  Recommendations
# 1 Initial bacteriological samples drawn from sites that are suspected as
the source of infection blood cultures in the first three hours
# 2 Initiating an empirical antibiotics therapy in the first three hours
# 3 Measurement of arterial lactate within the first six hours
# 4 Volume expansion ≥20 ml/kg within the first six hours
# 5 A targeted MAP > 65 mmHg within the first six hours
# 6 Assessments of CVP and ScvO2 within the first six hours
# 7 Glucose control ≤8.3 mmol/l within the first 24 hours
# 8 Low doses of corticosteroids when norepinephrine requirement at fewer than six hours
# 9 Using low tidal volume (≤8ml/kg of ideal body weight)
# 10 Adequate use of rhAPC within the first 24 hours
  1. CVP: central venous pressure; MAP: mean arterial pressure; rhAPC: recombinant human activated protein C; ScvO2: oxygen saturation of central venous haemoglobin