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Table 1 Comparison of baseline characteristics of patients with and without sepsis

From: Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study

  Patients
with sepsis
(N= 606)
Patients
without sepsis
(N= 819)
P-value Total cohort
(N= 1425)
28-day mortality n (%) 135 (22.3%) 36 (4.4%) < 0.001 171 (12.0%)
Gender (male) n (%) 385 (63.5%) 508 (62%) 0.56 893 (62.7%)
Age (y.o, IQR) 67 (55, 75) 65 (54, 73) 0.015 66 (54, 74)
APACHE II score (IQR) 21 (16, 25) 14 (10, 18) < 0.001 17 (12, 22)
Mechanical ventilation requirement n (%) 429 (70.8%) 528 (64.5%) 0.01 957 (67.2%)
Postoperative admission n (%) 68 (11.2%) 538 (65.7%) < 0.001 602 (42.2%)
Reasons for admission n (%)     
   Cardiac or vascular disease 109 (18.0%) 435 (53.1%) < 0.001 544 (38.2%)
   Thoracic or respiratory disease 343 (56.6%) 205 (25.0%) < 0.001 548 (38.4%)
   Renal or metabolic disease 61 (10.0%) 54 (6.6%) 0.018 115 (8.1%)
   Gastrointestinal tract disease 68 (11.2%) 108 (13.1%) 0.26 176 (12.4%)
   Other 25 (4.1%) 17 (2.1%) 0.024 42 (2.9%)
Length of stay in ICU 8 (5, 14) 5 (4, 7) < 0.001 6 (4, 10)
MAX ICU (°C, IQR) 38.3 (37.7, 39.0) 37.8 (37.4, 38.3) < 0.001 38.0 (37.5, 38.6)
   < 36.5°C 4 (0.7%) 2 (0.2%) 0.43 6 (0.4%)
   36.5°C to 37.4°C 98 (16.2%) 240 (29.3%) < 0.001 338 (23.7%)
   37.5°C to 38.4°C 237 (39.1%) 425 (52.0%) < 0.001 662 (46.5%)
   38.5°C to 39.4°C 185 (30.5%) 125 (15.3%) < 0.001 310 (21.8%)
   ≥ 39.5°C 82 (13.5%) 27 (3.3%) < 0.001 109 (7.6%)
NSAIDs     
   Number of patients administered n (%) 31 (5.1%) 99 (12.1%) < 0.001 130 (9.1%)
   Delta body temperature* (°C, IQR) -0.3 (-0.8, 0.0) -0.4 (-0.7, 0.0) 0.57 -0.3 (-0.7, 0.0)
Acetaminophen     
   Number of patients administered n (%) 116 (19.1%) 32 (3.9%) < 0.001 148 (10.4%)
   Delta body temperature* (°C, IQR) -0.4 (-0.8, -0.2) -0.3 (-0.7, 0.0) 0.14 -0.4 (-0.9, -0.2)
Physical cooling     
   Number of patients administered n (%) 307 (50.7%) 364 (44.4%) 0.02 671 (47.1%)
   Delta body temperature* (°C, IQR) -0.2 (-0.5, 0.0) -0.1 (-0.3, 0.0) < 0.001 -0.1 (-0.3, 0.0)
  1. APACHE, Acute Physiology and Chronic Health Evaluation; IQR, 25%, 75% interquartile; MAXICU, maximum body temperature during ICU stay; NSAIDs, non-steroid anti-inflammatory drugs
  2. *, Delta body temperature from application of antipyretic to next temperature monitoring