Table 1 AZD9773 dosing regimens
AZD9773 cohort 1 | AZD9773 cohort 2 | AZD9773 cohort 3 | AZD9773 cohort 4 | AZD9773 cohort 5 | |
|---|---|---|---|---|---|
Loading dose × 1 | 50 units/kg (over 90 minutes) | 250 units/kg (over 225 minutes for first three patients, then 95 minutes for next nine patients) | 250 units/kg (over 65 minutes for first three patients, then 60 minutes for next nine patients) | 500 units/kg (over 90 minutes for first three patients, then 60 minutes for next nine patients) | 750 units/kg (over 75 minutes for first three patients, then 60 minutes for next nine patients) |
Maintenance doses × 9 | 50 units/kg (over 30 minutes once every 12 hours) | 100 units/kg (over 30 minutes once every 12 hours) | 250 units/kg (over 30 minutes once every 12 hours) |