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Table 1 AZD9773 dosing regimens

From: A placebo-controlled, double-blind, dose-escalation study to assess the safety, tolerability and pharmacokinetics/pharmacodynamics of single and multiple intravenous infusions of AZD9773 in patients with severe sepsis and septic shock

  AZD9773 cohort 1 AZD9773 cohort 2 AZD9773 cohort 3 AZD9773 cohort 4 AZD9773 cohort 5
Loading dose × 1 50 units/kg
(over 90 minutes)
250 units/kg
(over 225 minutes for first three patients, then 95 minutes for next nine patients)
250 units/kg
(over 65 minutes for first three patients, then 60 minutes for next nine patients)
500 units/kg
(over 90 minutes for first three patients, then 60 minutes for next nine patients)
750 units/kg
(over 75 minutes for first three patients, then 60 minutes for next nine patients)
Maintenance doses × 9    50 units/kg
(over 30 minutes once every 12 hours)
100 units/kg
(over 30 minutes once every 12 hours)
250 units/kg
(over 30 minutes once every 12 hours)