A prospective randomized open-label crossover trial of regional citrate anticoagulation vs. anticoagulation free liver dialysis by the Molecular Adsorbents Recirculating System

Table 1 Heparin-free MARS studies

Study	Design	Indication	Total n	Heparin Free patients/sessions	Clotting n (P/S %)	Coagulopathy or Bleeding n (P/S %)	References
Doria et al. (2004)	retrospective	AoCLF/pruritus	9	9/74	0 (0/0%)	4 (44/nd%)	[6]
Tan et al. (2007)^a	retrospective	ALF/AoCLF	4	4/12	1 (25/8%)	1 (25/8%)	[8]
Bachli et al. (2007)	retrospective	ALF/AoCLF/pruritus	21	nd/40	nd	7 (nd/18%)	[7]
Yang et al (2008)^a	retrospective	ALF/AoCLF	10	5/13	1 (20/8%)	1 (20/8%)	[9]
Tan et al. (2010)^a	retrospective	ALF/AoCLF	12	12/44	11 (nd/25%)	4 (nd/9%)	[10]
Faybik et al.(2011)	Prospective	ALF/AoCLF	20	20/77	1 (5/1%)	1 (5/1%)	[15]

^aThese papers originate from the same research group. It is unclear whether these manuscripts report on the same patient population or not. ALF, acute liver failure; AoCLF, acute-on-chronic liver failure; MARS, Molecular Adsorbents Recirculation System; P, patients; S, sessions; nd, no data.

ISSN: 1364-8535