Skip to main content

Table 3 Comparison of haemodynamic changes in TRALI induced by either "stored PLT" or "stored PRBC"

From: Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI)

 

"stored PLT" (n= 4)

"stored PRBC" (n= 4)

P

PAP (mmHg)

24.4 ± 2.1

28.7 ± 2.4

0.0946

MAP (mmHg)

87.9 ± 5.5

74.5 ± 5.6

< 0.0001

CVP (mmHg)

3.0 ± 1.2

7.8 ± 1.2

< 0.0001

Heart rate (bpm)

112.7 ± 4.7

117.3 ± 5.4

0.5262

O2sat (%)

92.6 ± 2.8

89.5 ± 3.1

0.3598

EtCO2 (mmHg)

38.8 ± 3.0

33.3 ± 5.6

0.2253

CO (L/min)

4.9 ± 0.3

3.7 ± 0.4

< 0.05

SvO2 (%)

70.6 ± 5.9

62.3 ± 6.8

0.3499

Body temp (°C)

39.1. ± 0.3

40.3 ± 0.3

< 0.0001

PaO2 (mmHg)

103.9 ± 14.3

68.5 ± 16.4

0.1086

PaCO2 (mmHg)

42.7 ± 3.3

41.0 ± 3.7

0.7228

Cstat (L/kPa)

17.5 ± 3.0

15.7 ± 2.4

0.6305

PaO2/FiO2

259.8 ± 14.3

171.3 ± 16.4

0.1086

  1. CO, cardiac output; Cstat, static pulmonary compliance; CVP, central venous pressure; EtCO2, end tidal carbon dioxide; n, number of sheep in group; FiO2, fraction of inspired oxygen (= 40%); LPS, lipopolysaccharide; MAP, mean arterial pressure; O2sat, oxygen saturation; PaCO2, arterial partial pressure of carbon dioxide; PaO2, arterial partial pressure of oxygen; PAP, pulmonary artery pressure; "stored PLT", pooled heat-inactivated supernatant from Day 5 non-leucoreduced human platelet concentrates; "stored PRBC", pooled heat-inactivated supernatant from Day 42 non-leucoreduced human packed red blood cell concentrates; SEM, standard error of the mean; SvO2, mixed venous oxygen saturation; TRALI, transfusion-related acute lung injury. Averages ± SEM for each group are shown. Data and P-values were calculated using mixed modelling.
Back to article page

Critical Care

ISSN: 1364-8535