Volume 5 Supplement 1

21st International Symposium on Intensive Care and Emergency Medicine

Open Access

Systemic inflammatory response during ventilator-associated pneumonia

  • C Lepousé1,
  • B Hamou Ouali1,
  • A Zohir1,
  • J Cousson1,
  • JL Suinat1 and
  • A Léon1
Critical Care20015(Suppl 1):P049

https://doi.org/10.1186/cc1117

Received: 15 January 2001

Published: 2 March 2001

Introduction

Diagnosis of ventilator-associated pneumonia (VAP) can be difficult which often a large associated infectious or inflammatory diseases. The aim of our study was to describe systemic inflammatory response to VAP with the help of procalcitonin (PCT), CRP and cytokines.

Methods

In a prospective study, we studied all patients in our ICU with VAP between January 2000 and September 2000. PCT, CRP and cytokines (TNF, IL-6, IL-8) were measured at admission (J0), on second day (J2) and on fourth and seventh day (J4, J7). Prognostic indicators of severity were recorded on admission: Apache II, IGS II and SOFA score.

Results

Twenty-four consecutive patients (mean age 52 ± 17 years, mean IGS II 38 ± 15, mean Apache II 15 ± 6) were admitted in ICU. Mortality rate was 45% (11 patients).

Discussion

PCT seems to be a good marker of the intensity of inflammatory response to infection during VAP with PCT values often under 5 ng/ml. So higher PCT levels may be related to another sepsis and another aetiology must be researched.

Table 1

 

J0

J2

J4

J7

J14

PCT (ng/ml)

5.27 ± 14.14

6.01 ± 12.65

10.79 ± 26.26

10.52 ± 26.52

2.99 ± 8.44

CRP (mg/ml)

191 ± 68

215 ± 62

163 ± 92

147 ± 106

68 ± 84

TNF (pg/ml)

10 ± 9

8 ± 8

10 ± 9

IL-6 (pg/ml)

628 ± 1491

611 ± 1703

328 ± 602

IL-8 (pg/ml)

111 ± 248

78 ± 183

66 ± 129

Authors’ Affiliations

(1)
Hôpital R. Debré

Copyright

© The Author(s) 2001

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