- Meeting abstract
Systemic inflammatory response during ventilator-associated pneumonia
Critical Care volume 5, Article number: P049 (2001)
Diagnosis of ventilator-associated pneumonia (VAP) can be difficult which often a large associated infectious or inflammatory diseases. The aim of our study was to describe systemic inflammatory response to VAP with the help of procalcitonin (PCT), CRP and cytokines.
In a prospective study, we studied all patients in our ICU with VAP between January 2000 and September 2000. PCT, CRP and cytokines (TNF, IL-6, IL-8) were measured at admission (J0), on second day (J2) and on fourth and seventh day (J4, J7). Prognostic indicators of severity were recorded on admission: Apache II, IGS II and SOFA score.
Twenty-four consecutive patients (mean age 52 ± 17 years, mean IGS II 38 ± 15, mean Apache II 15 ± 6) were admitted in ICU. Mortality rate was 45% (11 patients).
PCT seems to be a good marker of the intensity of inflammatory response to infection during VAP with PCT values often under 5 ng/ml. So higher PCT levels may be related to another sepsis and another aetiology must be researched.
About this article
Cite this article
Lepousé, C., Hamou Ouali, B., Zohir, A. et al. Systemic inflammatory response during ventilator-associated pneumonia. Crit Care 5 (Suppl 1), P049 (2001). https://doi.org/10.1186/cc1117
- Public Health
- Mortality Rate
- Inflammatory Response
- Emergency Medicine