Skip to main content

Table 9 Studies evaluting von Willebrands factor

From: Clinical utility of biomarkers of endothelial activation in sepsis-a systematic review

Study Year N Population Standard criteria for SIRS/sepsis Association with sepsis Other outcomes
Claus et al., [89] 2009 63 ICU patients with severe sepsis (11), non-elective cardiac surgery (22), elective cardiac surgery as ICU controls (24), and post-exercise as healthy controls (6) 1992 ACCP/SCCM [1] VWF:Ag higher in patients with sepsis and post non-elective cardiac surgery than ICU controls (P < 0.05) VWF:Ag shows tendency to discriminate survivors from nonsurivors
Bockmeyer et al., [90] 2008 57 ICU patients with sepsis (11), non-elective cardiac surgery (22), and elective cardiac surgery as ICU controls (24) Not specified VWF:Ag higher in sepsis and in non-elective cardiac surgery than ICU controls (both P < 0.001) VWF:Ag correlated with mortality (P < 0.05)
van der Heijden et al., [45] 2008 112 Mechanically ventilated patients, with sepsis (24) and without (88) 1992 ACCP/SCCM [1] VWF higher in patients with sepsis than without sepsis (P < 0.001) VWF correlated with mortality (P = 0.006); VWF higher in those with ALI/ARDS than those without (P < 0.001)
Hovinga et al., [95] 2007 80 Medical and surgical ICU patients with severe sepsis or septic shock (40), and healthy controls (40) 1992 ACCP/SCCM [1] VWF:Ag and VWF:RCO higher in sepsis than controls (P < 0.001) VWF not correlated with disease severity, organ dysfunction, or mortality
Martin et al., [91] 2007 89 ICU patients with severe sepsis (30), sepsis-unrelated organ failure (29), and healthy controls (30) 1992 ACCP/SCCM [1] VWF:Ag tends to differentiate severe sepsis from sepsis-unrelated organ failure (P > 0.05) VWF:Ag not correlated with mortality
Scherpereel et al., [53] 2006 90 ICU patients with sepsis (63), SIRS (7), and healthy controls (20) 1992 ACCP/SCCM [1] VWF higher in sepsis than SIRS (P < 0.02) VWF correlated with mortality (P = 0.039)
Ware et al., [94] 2001 51 ICU patients with ALI, ARDS (45% due to sepsis) Temperature > 38° or < 35°C, systolic blood pressure < 90 mmHg (or a drop of 20 mm Hg or more in the systolic blood pressure from baseline), both present for at least 2 h; AND a clinically identifiable source of infection [103] VWF:Ag higher in patients with sepsis than those without (P < 0.05) VWF correlated with mortality (P < 0.005); higher in those with longer duration of ventilation P < 0.005; not correlated with illness severity scores (SAPSII, Lung Injury Score)
Garcia-Fernandez et al., [92] 2000 80 ICU patients with SIRS and acute renal failure (40), and healthy controls (40) 1992 ACCP/SCCM [1] VWF higher in SIRS than controls (P < 0.001)  
Bajaj et al., [97] 1999 60 Ward and ICU patients with ARDS (18), at risk of ARDS (15), and healthy controls (27) Clinical diagnosis of sepsis VWF does not differentiate patients with ARDS due to sepsis from other etiologies VWF higher in ARDS (P < 0.001) and at risk ARDS (P < 0.01) compared to controls but did not differ significantly between these two groups
Kayal et al., [59] 1998 41 ICU patients with severe sepsis or septic shock (25), ICU controls (7), healthy controls (9) 1992 ACCP/SCCM [1] VWF:Ag higher in sepsis than noninfected ICU controls and healthy controls (P < 0.0001); higher in septic shock than those without septic shock (P < 0.01) VWF:Ag correlated with mortality (P < 0.01); correlated with SAPS and MOF score (r = 0.57, P < 0.01 for MOF)
Moss et al., [66] 1996 66 ICU patients with sepsis (19), trauma (36), healthy controls (11) Clinical diagnosis of sepsis VWF:Ag higher in septic patients than trauma patients and controls (both P < 0.001)  
Moss et al., [98] 1995 96 Hospitalized patients at risk of ARDS, including sepsis (30) Clinical diagnosis of sepsis   VWF:Ag not predictive of the development of ARDS
Lorente et al., [93] 1993 48 ICU patients with septic shock 1992 ACCP/SCCM [1]   VWF:Ag not predictive of mortality
Rubin et al., [96] 1990 45 ICU patients with nonpulmonary sepsis Clinical diagnosis of sepsis   VWF:Ag correlated with mortality (P < 0.005) and ALI (P < 0.01)
  1. ACCP, American College of Chest Physicians; ALI, Acute Lung Injury; APACHE II, Acute Physiology and Chronic Health Evaluation II; ARDS, Acute Respiratory Distress Syndrome; ED, emergency department; MOF, Multiple Organ Failure; SAPS, Simplified Acute Physiology Score; SCCM, Society of Critical Care Medicine; SIRS, Systemic Inflammatory Response Syndrome; SOFA, Sequential Organ Failure Assessment