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Table 8 Studies evaluating Endothelin-1

From: Clinical utility of biomarkers of endothelial activation in sepsis-a systematic review

Study Year N Population Standard criteria for SIRS/sepsis Association with sepsis Other Outcomes
Schuetz et al., [81] 2007 95 Consecutive ICU admissions with SIRS, sepsis, septic shock 1992 ACCP/SCCM [1] Endothelin-1 rises with sepsis, septic shock, compared with SIRS (64.3, 131.6, 23.1 pmol/L, respectively; P < 0.01 between SIRS and sepsis, P < 0.05 between sepsis and septic shock) Endothelin-1 not correlated with mortality (p = 0.87)
Piechota et al., [85] 2007 20 Medical ICU patients with sepsis 1992 ACCP/SCCM [1], severity graded by procalcitonin and C-reactive protein level Endothelin-1 correlates with CRP and PCT levels as estimates of level of sepsis severity (P < 0.05 for both) Endothelin-1 correlates with SOFA score (p < 0.001)
Weitzberg et al., [86] 1991 16 Sepsis (6) and healthy controls (10) Bone et al., [102] Endothelin-1 elevated in sepsis compared with healthy controls (11.3 vs. 2.4 pmol/l, P < 0.01) n/a
Furian et al. [76] 2011 45 Patients admitted to ICU with severe sepsis or septic shock 1992 ACCP/SCCM [1]   Endothelin-1 levels associated with left ventricular and right ventricular function. (p = 0.002)
Pittet et al., [87] 1991 40 Sepsis (14), post-operative cardiac surgery (15) and healthy controls (11) Bone et al., [102] Endothelin-1 elevated in septic patients compared with healthy controls (19.9 vs 6.1 pg/ml, P < 0.0001) Endothelin-1 inversely correlated with cardiac index (p < 0.005); correlated with APACHE-II scores (p < 0.01)
  1. ACCP, American College of Chest Physicians; ALI, Acute Lung Injury; APACHE II, Acute Physiology and Chronic Health Evaluation II; ARDS, Acute Respiratory Distress Syndrome; ED, emergency department; MOF, Multiple Organ Failure; SAPS, Simplified Acute Physiology Score; SCCM, Society of Critical Care Medicine; SIRS, Systemic Inflammatory Response Syndrome; SOFA, Sequential Organ Failure Assessment