Skip to main content

Efficacy of tranexamic acid in decreasing blood loss during cesarean section


Despite significant progress in obstetric care, the problem of bleeding during labor remains unfinished. Annually in the world 125,000 women die from obstetric hemorrhage.


We performed a randomized, double-blind study in 37 patients who underwent cesarean section. Patients were divided into two groups: the first group (n = 19) received preoperative (30 minutes before operation) tranexamic acid 10 mg/kg; the second group (n = 18) received preoperative placebo. The condition of hemostasis was monitored by haemoviscoelastography.


All patients included in the study before the surgery had moderate hypercoagulation and normal fibrinolysis: increasing of the intensity of clot formation (ICF) to 11.4% compared to normal rates; the intensity of the retraction and clot lysis (IRCL) was 16.45 ± 1.40 in both groups. At the start of the operation in patients (group 1) - ICF decreased 9.7% (P < 0.05), and IRCL decreased 27.6% (P < 0.05) compared with preoperatively. In group 2, ICF decreased 8.8% (P < 0.05), and IRCL increased 11.4% (P < 0.05) compared with preoperatively. At the end of the operation, the condition of hemostasis in both groups came almost to the same value - moderate hypocoagulation, depressed fibrinolysis. In both groups there were no thrombotic complications. Intraoperative blood loss in the first group was 300 ± 40.5 and in the second was 500 ± 60.6.


Using tranexamic acid before surgery significantly reduces intraoperative blood loss by 40%, without thrombotic complications.

Author information

Authors and Affiliations


Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Cite this article

Tarabrin, O., Kaminskiy, V., Galich, S. et al. Efficacy of tranexamic acid in decreasing blood loss during cesarean section. Crit Care 16, P439 (2012).

Download citation

  • Published:

  • DOI:


  • Public Health
  • Placebo
  • Blood Loss
  • Normal Rate
  • Cesarean Section