Skip to main content

Transcranial cerebral oximetry in newborn infants on mechanical ventilation as a method for prevention of hyperoxia and oxidative stress


The aim of this research was the effectiveness of respiratory therapy in infants with respiratory distress syndrome (RDS) who are ventilated by correcting the oxygen status and parameter optimization of ventilation by determining the oxygen saturation in the brain by transcranial cerebral oximetry (TCO).


A total of 24 infants born in the physiological department of a maternity hospital in RNIIAP was studied. All of the children were measured for the saturation of brain tissue oxygen (SctL, SctR) with a cerebral oximeter (ForeSight; USA) at 1, 3 and 5 days after birth. Later in the study, two groups of newborn infants on mechanical ventilation were included. Patients of group 1 (n = 38), modes of mechanical ventilation and FiO2 were determined under control TCO to bring rates of cerebral oxygenation to the age norm. Patients of group 2 (n = 37), mode selection and ventilator FiO2 were carried out under the control of pulse oximetry and partial oxygen tension (pO2) in acid-base balance, without regard for performance of TCO. In all patients were determined serum peroxides (Oxystat test; BIOMEDICA GRUPPE, Germany), as well as the oxidation products of proteins (AOPP) in the serum of a set of AOPP (Immunodiagnostik, USA) for 1, 5 and 10 days. We measured blood gas parameters with an automatic analyzer (ABL; Denmark).


Determined by the age norm, TCO indicators for healthy infants amounted in the left hemisphere of the brain to 79.2 ± 4.06% (P < 0.01), and in the right hemisphere to 84.89 ± 5.1% (P < 0.01). We established in the group of infants where the mode selection ventilation and FiO2 were carried out on the basis of TCO indicators, an average FiO2 in the inspired mixture of 21% with an average pO2 in blood capillaries 61.95 ± 20.16%, in contrast to FiO2 55% with pO2 -78.01 ± 18.93% in patients of group 2. Patients of group 1 showed significantly (in all cases P < 0.01) decreased length of stay on mechanical ventilation (from 9.4 to 5.6 bed-days), compared with the control group. Investigation of the activity markers of oxidative stress showed three times reduction of the oxidation products of proteins (AOPP) and twofold reduction of peroxides in patients in the study group, compared with the control group, to 10 days of observation (P < 0.05).


Monitoring of oxygen saturation in the brain tissue by TCO in infants with RDS reduces the mortality rate and the term of mechanical ventilation and hyperoxia.

Author information

Authors and Affiliations


Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Cite this article

Estrin, V., Simonova, A. Transcranial cerebral oximetry in newborn infants on mechanical ventilation as a method for prevention of hyperoxia and oxidative stress. Crit Care 16, P293 (2012).

Download citation

  • Published:

  • DOI:


  • Mechanical Ventilation
  • Respiratory Distress Syndrome
  • Pulse Oximetry
  • Newborn Infant
  • Mode Selection