Skip to content

Advertisement

Open Access

Lactate in burn patients: biomarker of sepsis and mortality

  • A Mokline1,
  • L Gharsallah1,
  • A Abdenneji1,
  • H Oueslati1,
  • I Rahmani1,
  • B Gasri1,
  • I Jami1,
  • A Ghanem1 and
  • A Messadi1
Critical Care201216(Suppl 1):P258

https://doi.org/10.1186/cc10865

Published: 20 March 2012

Keywords

LactatePowerful PredictorCare CenterGood SensitivityThermal Injury

Introduction

In this study, we attempted to assess whether the early plasma lactate (PL) level is a useful biomarker to predict septic complications and outcome in burn patients.

Methods

A retrospective study was conducted in the burn care center in Tunis. Patients admitted within 24 hours from the thermal injury, from 1 January 2009 to 30 June 2010, were included. PL was measured early in the first 24 hours and controlled more than twice. For each measurement, 5 ml venous blood was drawn into a heparin-coated syringe. The normal lactate value was defined as 1 ± 0.5 mmol/l.

Results

Over an 18-month period of study, 80 patients were enrolled. There were 60 males and 20 females. The mean age was 40.7 ± 19.5 and the average TBSA was 32 ± 21%. Upon admission, patients with an initial lactate value of more than 2 mmol/l were 86.7%. Fifty-eight percent of them have a lactate initial value of more than 4 mmol/l. In order to evaluate the potential impact of using early lactate measurements (H24 post burn injury) as predictor biomarker of sepsis in burn patients, a linear discrimination function was performed, by measuring the area under the ROC curve, and found that initial lactate value of more than 4 mmol/l provides the best sensitivity and specificity: 88% and 79% respectively. Also, the PL cut-off value for prediction of mortality was 4 mmol/l with a good sensitivity (86%) and specificity (92%). The area under the ROC curve was 0.96.

Conclusion

Lactate appears to be a powerful predictor biomarker of sepsis and mortality in burn patients. A serum lactate of 4 mmol/l provides the best sensitivity and specificity.

Authors’ Affiliations

(1)
Burn and Trauma Center, Tunis, Tunisia

Copyright

© Mokline et al.; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Advertisement