Volume 16 Supplement 1

32nd International Symposium on Intensive Care and Emergency Medicine

Open Access

Computer-based monitoring of global cardiovascular dynamics during acute pulmonary embolism and septic shock in swine

  • JA Revie1,
  • DJ Stevenson1,
  • JG Chase1,
  • BC Lambermont2,
  • A Ghuysen2,
  • P Kolh2,
  • GM Shaw3 and
  • T Desaive2
Critical Care201216(Suppl 1):P228


Published: 20 March 2012


Acute pulmonary embolism (APE) and septic shock (SS) are highly prevalent dysfunctions in the ICU due to the immunocompromised and immobile state of ICU patients. This research retrospectively tests the ability of a computer-based method to monitor acute hemodynamic changes in pigs. If proven, this method could assist ICU staff by providing a clear physiological, patient-specific picture of cardiovascular status for decision support.


In two porcine studies, APE (n = 5) and SS (n = 4) were induced using autologous blood clots and endotoxin infusions. Hemodynamic measurements were recorded every 30 minutes for 4 hours (n = 80). Subject-specific cardiovascular models were identified from typical ICU measurements obtained from each of these datasets, including aortic and pulmonary artery pressure, stroke volume, heart rate, global end-diastolic volume, and mitral and tricuspid valve closure times. Model outputs and identified parameters were compared to experimentally derived indices, measurements not used in the identification process, and known trends to validate the accuracy of the models.


The models accurately predicted maximum ventricular pressures and volumes, not used in the identification process, to mean percentage errors of 7.1% and 6.7% (less than measurement error ~10%). Mean modelled pulmonary vascular resistances (PVR) compared well (R2 = 0.81 for APE and R2 = 0.95 for SS) to experimentally derived values. Importantly, in the APE study a 91% rise from baseline in the mean PVR was identified with an 89% increase seen in the SS pigs. Contrasting behaviour between the two studies was observed for systemic vascular resistance (SVR) with a maximum drop of 40% from baseline recorded at T120 for SS, indicating a loss of vascular tone as expected, where at the same time in the APE study the average SVR had increased by 13%. An increase in the ratio of right to left ventricle end volume was identified in all nine pigs, indicating right ventricular distension and a leftward shift in the intraventricular septum.


These results indicate that subject-specific cardiovascular models are capable of tracking well-known global hemodynamic trends of two common forms of shock in the ICU. The method shows potential and could provide a means for continuous cardiovascular monitoring at little extra cost as no extra measurements or expensive devices are required.

Authors’ Affiliations

University of Canterbury
University of Liege
Christchurch Hospital


© Revie et al.; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.