- Poster presentation
- Open access
- Published:
IL-17A rs1974226 GG genotype is associated with increased susceptibility to Gram-positive infection and mortality of severe sepsis
Critical Care volume 16, Article number: P2 (2012)
Introduction
IL-17A plays a key role in host defense against microbial infection including Gram-positive bacteria. Genetic factors contribute to the host defense. Whether genetic variation of IL-17A is associated with altered clinical outcome of severe sepsis is unknown.
Methods
We tested for genetic association of IL-17A SNPs with susceptibility to infection and clinical outcome of severe sepsis using two cohorts of European ancestry (St Paul's Hospital (SPH) derivation cohort, n = 679; Vasopressin and Septic Shock Trial (VASST) validation cohort n = 517). The primary outcome variable was susceptibility to Gram-positive bacterial infection. The secondary outcome variable was 28-day mortality.
Results
Of four tested tag SNPs (rs4711998, rs8193036, rs2275913, rs1974226) in the IL-17A gene, rs1974226 SNP was associated with altered susceptibility to Gram-positive bacterial infection in the derivation cohort (corrected P = 0.014). Patients who have the GG genotype of the rs1974226 SNP were more susceptible to Gram-positive bacterial infection, compared to the AG/AA genotype in the two cohorts of severe sepsis (SPH, P = 0.0036; VASST, P = 0.011) and in the subgroup having lung infection (P = 0.017). Furthermore, the G allele of the IL-17A rs1974226 SNP was associated with increased 28-day mortality in two cohorts (SPH, adjusted OR 1.44, 95% CI 1.04 to 2.02, P = 0.029; VASST, adjusted OR 1.67, 95% CI 1.17 to 2.40, P = 0.0052).
Conclusion
IL-17A genetic variation is associated with altered susceptibility to Gram-positive infection and 28-day mortality of severe sepsis.
References
Puel A, et al.: Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science 2011, 332: 65-68. 10.1126/science.1200439
Cho JS, et al.: IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest 2010, 120: 1762-1773. 10.1172/JCI40891
Author information
Authors and Affiliations
Rights and permissions
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Nakada, T., Russell, J., Boyd, J. et al. IL-17A rs1974226 GG genotype is associated with increased susceptibility to Gram-positive infection and mortality of severe sepsis. Crit Care 16 (Suppl 1), P2 (2012). https://doi.org/10.1186/cc10609
Published:
DOI: https://doi.org/10.1186/cc10609