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Table 1 Differences between HYPOLYTE and CRASH studies

From: Glucocorticoid therapy for trauma - ready for prime time?

  CRASH STUDY HYPOLYTE STUDY
Number of patients 10,000 150
Primary end point Mortality Pneumonia incidence
Time to administration of first dose of steroid < 8 hours Within 36 hours of trauma; 25 hours (median)
Steroid loading dose 2 gms None
Duration of Steroids 48 hours 1 week