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Table 3 Changes in patients' tolerance to ventilation

From: Optimization of ventilator setting by flow and pressure waveforms analysis during noninvasive ventilation for acute exacerbations of COPD: a multicentric randomized controlled trial

  All patients Optimized ventilation Standard ventilation P
At the beginning of NIV     
   Tolerance to ventilation 1.5 ± .7 1.5 ± .7 1.5 ± .6 .928
   Inspiratory difficulty 7.2 ± 1.9 7.2 ± 2.2 7.2 ± 1.6 1.000
   Expiratory difficulty 7.2 ± 2.0 7.1 ± 1.9 7.3 ± 2.1 .735
After 30 minutes of NIV     
   Tolerance to ventilation 2.6 ± .9 2.7 ± .8 2.6 ± .9 .663
   Inspiratory difficulty 5.4 ± 1.3 5.2 ± 2.2 5.6 ± 2.0 .555
   Expiratory difficulty 5.6 ± 2.0 5.3 ± 2.1 5.9 ± 1.8 .304
   Pts Alarm activation*, n 2.2 ± 3.1 1.9 ± 1.7 2.5 ± 1.9 .416
After 2 hours of NIV     
   Tolerance to ventilation 2.3 ± 8 2.6 ± .7 1.9 ± .9 .001
   Inspiratory difficulty 4.9 ± 1.9 4.7 ± 1.9 5.0 ± 1.9 .494
   Expiratory difficulty 4.8 ± 2.0 4.8 ± 2.0 4.9 ± 2.0 .875
   Pts Alarm activation*, n 1.9 ± 2.8 1.0 ± 1.9 3.3 ± 3.2 .004
After 6 hours of NIV     
   Tolerance to ventilation 3.5 ± .8 3.7 ± .7 3.3 ± .9 .092
   Inspiratory difficulty 4.0 ± 2.1 3.7 ± 2.1 4.2 ± 2.2 .442
   Expiratory difficulty 3.9 ± 2.1 3.5 ± 2.0 4.4 ± 2.2 .124
   Pts Alarm activation*, n 2.3 ± 2.8 1.1 ± 1.8 3.4 ± 3.2 .015
After 24 hours of NIV     
   Tolerance to ventilation 3.8 ± 1.0 3.8 ± 1.0 3.8 ± 1.0 .921
   Inspiratory difficulty 3.1 ± 2.1 3.0 ± 2.2 3.2 ± 2.1 .791
   Expiratory difficulty 3.2 ± 2.3 3.1 ± 2.5 3.4 ± 2.1 .657
   Pts Alarm activation*, n 2.3 ± 3.0 1.1 ± 1.8 3.4 ± 3.2 .387
  1. Data reported as mean ± standard deviation. Pts, patients. *Data available in 40 patients. Significant differences in bold.