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Table 3 Changes in patients' tolerance to ventilation

From: Optimization of ventilator setting by flow and pressure waveforms analysis during noninvasive ventilation for acute exacerbations of COPD: a multicentric randomized controlled trial

 

All patients

Optimized ventilation

Standard ventilation

P

At the beginning of NIV

    

   Tolerance to ventilation

1.5 ± .7

1.5 ± .7

1.5 ± .6

.928

   Inspiratory difficulty

7.2 ± 1.9

7.2 ± 2.2

7.2 ± 1.6

1.000

   Expiratory difficulty

7.2 ± 2.0

7.1 ± 1.9

7.3 ± 2.1

.735

After 30 minutes of NIV

    

   Tolerance to ventilation

2.6 ± .9

2.7 ± .8

2.6 ± .9

.663

   Inspiratory difficulty

5.4 ± 1.3

5.2 ± 2.2

5.6 ± 2.0

.555

   Expiratory difficulty

5.6 ± 2.0

5.3 ± 2.1

5.9 ± 1.8

.304

   Pts Alarm activation*, n

2.2 ± 3.1

1.9 ± 1.7

2.5 ± 1.9

.416

After 2 hours of NIV

    

   Tolerance to ventilation

2.3 ± 8

2.6 ± .7

1.9 ± .9

.001

   Inspiratory difficulty

4.9 ± 1.9

4.7 ± 1.9

5.0 ± 1.9

.494

   Expiratory difficulty

4.8 ± 2.0

4.8 ± 2.0

4.9 ± 2.0

.875

   Pts Alarm activation*, n

1.9 ± 2.8

1.0 ± 1.9

3.3 ± 3.2

.004

After 6 hours of NIV

    

   Tolerance to ventilation

3.5 ± .8

3.7 ± .7

3.3 ± .9

.092

   Inspiratory difficulty

4.0 ± 2.1

3.7 ± 2.1

4.2 ± 2.2

.442

   Expiratory difficulty

3.9 ± 2.1

3.5 ± 2.0

4.4 ± 2.2

.124

   Pts Alarm activation*, n

2.3 ± 2.8

1.1 ± 1.8

3.4 ± 3.2

.015

After 24 hours of NIV

    

   Tolerance to ventilation

3.8 ± 1.0

3.8 ± 1.0

3.8 ± 1.0

.921

   Inspiratory difficulty

3.1 ± 2.1

3.0 ± 2.2

3.2 ± 2.1

.791

   Expiratory difficulty

3.2 ± 2.3

3.1 ± 2.5

3.4 ± 2.1

.657

   Pts Alarm activation*, n

2.3 ± 3.0

1.1 ± 1.8

3.4 ± 3.2

.387

  1. Data reported as mean ± standard deviation. Pts, patients. *Data available in 40 patients. Significant differences in bold.