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Table 7 Evidence for the effect of each intervention on survival

From: Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review

 

FFP outcomes: survival

Fibrinogen concentrate outcomes: survival

Type of study

Improvement

No difference

Reduction

Improvement

No difference

Reduction

RCT

-

-

1 (1 to 32 days) [38]

1 (in-hospital) [78]

-

-

-

Non RCT or prospective comparator

-

1 (in-hospital) [87]

1 (in-hospital) [77]

-

-

-

Retrospective comparator

2 (6 hours) [68, 81]

3 (24 hours) [4, 67, 81]

7 (30 days) [3, 4, 28, 39, 42, 69, 81]

1 (90 days) [69]

7 (in-hospital) [31–34, 67, 68, 86, 90, 91]

4 (30 days) [66, 84, 85, 93]

1 (36 months) [40]

6 (in-hospital) [31, 67, 76, 79, 83, 89]

1 (30 days) [92]

1 (1 year) [82]

1 (10 years) [88]

2 (in-hospital) [75, 80]

-

1 (30 days) [26]

-

Controlled and/or comparator study outcomes, n (percentage of all outcomes within intervention group)

20 (50%)

12 (30%)

8 (20%)

0

1 (100%)

0

Prospective noncomparator

1 (24 hours) [97]

-

1 (in-hospital) [95]

-

-

-

Retrospective noncomparator

2* (in-hospital) [99, 103]

1 (6 months) [101]

1 (1 year) [102]

1 (68 months) [100]

2* (in-hospital) [96, 103]

1 (at 6 months) [101]

2 (in-hospital) [94, 98]

1 (7 days) [104]

1 (in-hospital) [73]

-

-

Case report

-

-

-

-

-

-

Study outcomes, n (percentage of outcomes within intervention group)

23 (44%)

17 (33%)

12 (23%)

2 (67%)

1 (33%)

0

  1. FFP = fresh frozen plasma; RCT = randomised, controlled trial; - = no data. *Primary analysis excluding early deaths < 48 hours) revealed no association with FFP administration and survival. Secondary analysis including all patients revealed an association with decreased mortality [103].