| FFP outcomes: survival | Fibrinogen concentrate outcomes: survival | ||||
---|---|---|---|---|---|---|
Type of study | Improvement | No difference | Reduction | Improvement | No difference | Reduction |
RCT | - | - | 1 (1 to 32 days) [38] 1 (in-hospital) [78] | - | - | - |
Non RCT or prospective comparator | - | 1 (in-hospital) [87] | 1 (in-hospital) [77] | - | - | - |
Retrospective comparator | 7 (30 days) [3, 4, 28, 39, 42, 69, 81] 1 (90 days) [69] | 1 (36 months) [40] | 1 (30 days) [92] 1 (1 year) [82] 1 (10 years) [88] | - | 1 (30 days) [26] | - |
Controlled and/or comparator study outcomes, n (percentage of all outcomes within intervention group) | 20 (50%) | 12 (30%) | 8 (20%) | 0 | 1 (100%) | 0 |
Prospective noncomparator | 1 (24 hours) [97] | - | 1 (in-hospital) [95] | - | - | - |
Retrospective noncomparator | 1 (6 months) [101] 1 (1 year) [102] 1 (68 months) [100] | 1 (at 6 months) [101] | 1 (7 days) [104] 1 (in-hospital) [73] | - | - | |
Case report | - | - | - | - | - | - |
Study outcomes, n (percentage of outcomes within intervention group) | 23 (44%) | 17 (33%) | 12 (23%) | 2 (67%) | 1 (33%) | 0 |