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Table 7 Evidence for the effect of each intervention on survival

From: Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review

  FFP outcomes: survival Fibrinogen concentrate outcomes: survival
Type of study Improvement No difference Reduction Improvement No difference Reduction
RCT - - 1 (1 to 32 days) [38]
1 (in-hospital) [78]
- - -
Non RCT or prospective comparator - 1 (in-hospital) [87] 1 (in-hospital) [77] - - -
Retrospective comparator 2 (6 hours) [68, 81]
3 (24 hours) [4, 67, 81]
7 (30 days) [3, 4, 28, 39, 42, 69, 81]
1 (90 days) [69]
7 (in-hospital) [3134, 67, 68, 86, 90, 91]
4 (30 days) [66, 84, 85, 93]
1 (36 months) [40]
6 (in-hospital) [31, 67, 76, 79, 83, 89]
1 (30 days) [92]
1 (1 year) [82]
1 (10 years) [88]
2 (in-hospital) [75, 80]
- 1 (30 days) [26] -
Controlled and/or comparator study outcomes, n (percentage of all outcomes within intervention group) 20 (50%) 12 (30%) 8 (20%) 0 1 (100%) 0
Prospective noncomparator 1 (24 hours) [97] - 1 (in-hospital) [95] - - -
Retrospective noncomparator 2* (in-hospital) [99, 103] 1 (6 months) [101]
1 (1 year) [102]
1 (68 months) [100]
2* (in-hospital) [96, 103]
1 (at 6 months) [101]
2 (in-hospital) [94, 98]
1 (7 days) [104]
1 (in-hospital) [73]
- -
Case report - - - - - -
Study outcomes, n (percentage of outcomes within intervention group) 23 (44%) 17 (33%) 12 (23%) 2 (67%) 1 (33%) 0
  1. FFP = fresh frozen plasma; RCT = randomised, controlled trial; - = no data. *Primary analysis excluding early deaths < 48 hours) revealed no association with FFP administration and survival. Secondary analysis including all patients revealed an association with decreased mortality [103].