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Table 2 Summary details of eligible comparator trials

From: Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review

Study Indication Study type N(intervention group vs controls) Intervention details Control group
FFP
Antolovic et al.
(2008) [75]
Surgery (ischaemic colitis) Retrospective comparator 81 (30 vs 51) FFP ≥ 3 U FFP < 3 U
Apaydin et al.
(2002) [76]
CV surgery Retrospective comparator 85 (16 vs 69) FFP > 2 U FFP ≤ 2 U
Bochicchio et al.
(2008) [77]
Trauma Prospective comparator 922 FFP mean 5.4 U No FFP
Borgman et al.
(2007) [34]
Massive trauma Retrospective comparator 246 FFP:RBC high 1:1.4 FFP:RBC 1:2.5 and 1:8
Chowdhury et al.
(2004) [109]
Various Prospective comparator 22 (10 vs 12) FFP standard dose median 12.2 ml/kg FFP high dose median 33.5 ml/kg
Dente et al.
(2009) [30]
Massive trauma Prospective cohort vs historical control 157 (73 vs 84) FFP:RBC ≥ 1:2 (MTP) FFP:RBC < 1:2 (pre MTP)
Duchesne et al.
(2008/2009/2010)
[3133]
Massive trauma, surgery (TIC), trauma Retrospective comparator 385/135/196 FFP:RBC 1:1 Ratios outside 1:1
   Gunter (2008) et al. [28] Massive trauma Prospective cohort vs historical control 259 (64 vs 195) FFP:RBC 1:1 to 1:1.5 FFP:RBC < 1:1.5 and > 1:1
Hildebrandt (2007)
et al. [23] and
Kerner et al.
(2008) [24]
Surgery (craniofacial, infants) Non RCT 30 (15 vs 15) FFP mean 45 ml/kg 5% human albumin
Holcomb et al.
(2008)
[3]
Massive trauma Retrospective comparator 466 FFP:RBC ≥ 1:2 FFP:RBC < 1:2
Inaba et al. (2010)
[79]
Trauma (nonmassive transfusion) Retrospective matched cohort 568 (284 vs 284) FFP mean 3.0 U No FFP
Johansson et al.
(2007) [39]
CV surgery Prospective cohort vs historical control 148 (55 vs 93) FFP:RBC 1:1 (transfusion package) mean 10 U FFP:RBC < 1:1 (pre transfusion package) mean 7 U
Johansson et al.
(2009) [69]
Surgery (various) with massive transfusion Prospective cohort vs historical control 832 (442 vs 390) FFP:RBC 1:1.3 (transfusion package) FFP:RBC 1:1.6 (pre transfusion package)
Kaibori et al.
(2008) [40]
Surgery (hepatectomy for hepatocellular carcinoma) Retrospective comparator 184 (43 vs 141) FFP median 4.0 U No FFP
Kashuk et al.
(2008) [80]
Massive trauma Retrospective comparator 133 FFP:RBC 1:1 FFP:RBC 1:2, 1:3, 1:4 or 1:5
Koch et al. (2009)
[105]
CV surgery Retrospective matched cohort 1928 (964 vs 964) FFP, dose not reported No FFP
Maegele et al.
(2008) [81]
Massive trauma Retrospective comparator 713 FFP:RBC 1:1 FFP:RBC < 0.9:1 and > 1.1:1
Massicotte et al.
(2005) [82]
Liver transplantation Retrospective comparator 66 (26 vs 40) FFP mean 4.9 U No FFP
Mell et al. (2010)
[42]
CV surgery Retrospective comparator 128 (87 vs 41) FFP:RBC ≥ 1:2 FFP:RBC < 1:2
Miller et al. (1997)
[44]
CV surgery (paediatric) Prospective comparator 36 (19 vs 17) FFP, dose not reported Cryoprecipitate, dose not reported
Mitra et al. (2010)
[66]
Massive trauma Retrospective comparator 331 FFP:RBC > 1:1.5 FFP:RBC < 1:1.5
Oberkofler et al.
(2010) [83]
Liver transplantation Retrospective comparator 144 FFP > 10 U FFP < 10 U
Ono et al. (2002)
[84]
CV surgery Retrospective comparator 60 (39 vs 21) FFP 3.2 U No FFP
Reed et al. (1986)
[46]
Trauma Prospective cohort vs published data 40 (16 vs 24) FFP 2 U/12 U blood No FFP
Riskin et al.
(2009) [85]
Massive trauma Retrospective comparator 77 FFP:RBC 1:1.8 (MTP) FFP:RBC 1:1.8 (pre MTP)
Rose et al. (2009)
[86]
Massive trauma Retrospective comparator 204 FFP:RBC 1:1 FFP:RBC < 0.9:1 and > 1.1:1
Roy et al. (1988)
[47]
CV surgery Retrospective comparator (sequential cohorts) 100 (52 vs 48) FFP mean 5.8 U 5% albumin
Scalea et al. (2008)
[87]
Trauma Prospective comparator 250 FFP:RBC 1:1 Ratios outside 1:1
Scheele et al.
(2001) [88]
Surgery (liver resection for colorectal metastases) Retrospective comparator 425 (159 vs 308) FFP, dose not reported No FFP
Shaz et al. (2010)
[4]
Massive trauma Retrospective comparator 214 FFP:RBC ≥ 1:2 FFP:RBC < 1:2
Snyder et al.
(2009) [89]
Massive trauma Retrospective comparator 134 (60 vs 74) FFP:RBC ≥ 1:2 FFP:RBC < 1:2
Sperry et al.
(2008) [67]
Massive trauma Retrospective comparator 415 FFP:RBC ≥ 1:1.5 FFP:RBC < 1:1.5
Stinger et al.
(2008) [90]
Massive trauma Retrospective comparator 252 FFP high fibrinogen:RBC > 0.2 g fibrinogen/1 U RBC) FFP low fibrinogen:RBC < 0.2 g fibrinogen/1 U RBC)
Teixeira et al.
(2009) [91]
Massive trauma Retrospective comparator 383 FFP:RBC > 1:2 FFP:RBC < 1:8, 1:8 to 1:3 and 1:3 to 1:2
Tomimaru et al.
(2010) [92]
Surgery (hepatectomy for hepatocellular carcinoma) Retrospective comparator 497 (204 vs 293) FFP median 10 U No FFP (in 93% of patients in the group)
Wright et al.
(2008)
[93]
CV surgery Retrospective comparator 211 (129 vs 82) FFP (mixed donors) median 6 U FFP (male-only donors) median 4 U
Zink et al. (2009)
[68]
Massive trauma Retrospective comparator 466 FFP:RBC ≥ 1:1 FFP:RBC < 1:1
Fibrinogen concentrate
Rahe-Meyer et al.
(2009) [55]
CV surgery Non RCT 15 (10 vs 5) Fibrinogen concentrate mean 5.7 g FFP mean 4.2 U
Rahe-Meyer et al.
(2009) [26]
CV surgery Prospective cohort vs historical control 18 (6 vs 12) Fibrinogen concentrate mean 7.2 g FFP mean 9.1 U
  1. CV = cardiovascular; FFP = fresh frozen plasma; MTP = massive transfusion protocol; RBC = packed red blood cells; RCT = randomised, controlled trial; TIC = trauma-induced coagulopathy.