Table 2 Summary details of eligible comparator trials
Study | Indication | Study type | N(intervention group vs controls) | Intervention details | Control group |
|---|---|---|---|---|---|
FFP | |||||
Antolovic et al. (2008) [75] | Surgery (ischaemic colitis) | Retrospective comparator | 81 (30 vs 51) | FFP ≥ 3 U | FFP < 3 U |
Apaydin et al. (2002) [76] | CV surgery | Retrospective comparator | 85 (16 vs 69) | FFP > 2 U | FFP ≤ 2 U |
Bochicchio et al. (2008) [77] | Trauma | Prospective comparator | 922 | FFP mean 5.4 U | No FFP |
Borgman et al. (2007) [34] | Massive trauma | Retrospective comparator | 246 | FFP:RBC high 1:1.4 | FFP:RBC 1:2.5 and 1:8 |
Chowdhury et al. (2004) [109] | Various | Prospective comparator | 22 (10 vs 12) | FFP standard dose median 12.2 ml/kg | FFP high dose median 33.5 ml/kg |
Dente et al. (2009) [30] | Massive trauma | Prospective cohort vs historical control | 157 (73 vs 84) | FFP:RBC ≥ 1:2 (MTP) | FFP:RBC < 1:2 (pre MTP) |
Duchesne et al. (2008/2009/2010) | Massive trauma, surgery (TIC), trauma | Retrospective comparator | 385/135/196 | FFP:RBC 1:1 | Ratios outside 1:1 |
   Gunter (2008) et al. [28] | Massive trauma | Prospective cohort vs historical control | 259 (64 vs 195) | FFP:RBC 1:1 to 1:1.5 | FFP:RBC < 1:1.5 and > 1:1 |
Hildebrandt (2007) et al. [23] and Kerner et al. (2008) [24] | Surgery (craniofacial, infants) | Non RCT | 30 (15 vs 15) | FFP mean 45 ml/kg | 5% human albumin |
Holcomb et al. (2008) [3] | Massive trauma | Retrospective comparator | 466 | FFP:RBC ≥ 1:2 | FFP:RBC < 1:2 |
Inaba et al. (2010) [79] | Trauma (nonmassive transfusion) | Retrospective matched cohort | 568 (284 vs 284) | FFP mean 3.0 U | No FFP |
Johansson et al. (2007) [39] | CV surgery | Prospective cohort vs historical control | 148 (55 vs 93) | FFP:RBC 1:1 (transfusion package) mean 10 U | FFP:RBC < 1:1 (pre transfusion package) mean 7 U |
Johansson et al. (2009) [69] | Surgery (various) with massive transfusion | Prospective cohort vs historical control | 832 (442 vs 390) | FFP:RBC 1:1.3 (transfusion package) | FFP:RBC 1:1.6 (pre transfusion package) |
Kaibori et al. (2008) [40] | Surgery (hepatectomy for hepatocellular carcinoma) | Retrospective comparator | 184 (43 vs 141) | FFP median 4.0 U | No FFP |
Kashuk et al. (2008) [80] | Massive trauma | Retrospective comparator | 133 | FFP:RBC 1:1 | FFP:RBC 1:2, 1:3, 1:4 or 1:5 |
Koch et al. (2009) [105] | CV surgery | Retrospective matched cohort | 1928 (964 vs 964) | FFP, dose not reported | No FFP |
Maegele et al. (2008) [81] | Massive trauma | Retrospective comparator | 713 | FFP:RBC 1:1 | FFP:RBC < 0.9:1 and > 1.1:1 |
Massicotte et al. (2005) [82] | Liver transplantation | Retrospective comparator | 66 (26 vs 40) | FFP mean 4.9 U | No FFP |
Mell et al. (2010) [42] | CV surgery | Retrospective comparator | 128 (87 vs 41) | FFP:RBC ≥ 1:2 | FFP:RBC < 1:2 |
Miller et al. (1997) [44] | CV surgery (paediatric) | Prospective comparator | 36 (19 vs 17) | FFP, dose not reported | Cryoprecipitate, dose not reported |
Mitra et al. (2010) [66] | Massive trauma | Retrospective comparator | 331 | FFP:RBC > 1:1.5 | FFP:RBC < 1:1.5 |
Oberkofler et al. (2010) [83] | Liver transplantation | Retrospective comparator | 144 | FFP > 10 U | FFP < 10 U |
Ono et al. (2002) [84] | CV surgery | Retrospective comparator | 60 (39 vs 21) | FFP 3.2 U | No FFP |
Reed et al. (1986) [46] | Trauma | Prospective cohort vs published data | 40 (16 vs 24) | FFP 2 U/12 U blood | No FFP |
Riskin et al. (2009) [85] | Massive trauma | Retrospective comparator | 77 | FFP:RBC 1:1.8 (MTP) | FFP:RBC 1:1.8 (pre MTP) |
Rose et al. (2009) [86] | Massive trauma | Retrospective comparator | 204 | FFP:RBC 1:1 | FFP:RBC < 0.9:1 and > 1.1:1 |
Roy et al. (1988) [47] | CV surgery | Retrospective comparator (sequential cohorts) | 100 (52 vs 48) | FFP mean 5.8 U | 5% albumin |
Scalea et al. (2008) [87] | Trauma | Prospective comparator | 250 | FFP:RBC 1:1 | Ratios outside 1:1 |
Scheele et al. (2001) [88] | Surgery (liver resection for colorectal metastases) | Retrospective comparator | 425 (159 vs 308) | FFP, dose not reported | No FFP |
Shaz et al. (2010) [4] | Massive trauma | Retrospective comparator | 214 | FFP:RBC ≥ 1:2 | FFP:RBC < 1:2 |
Snyder et al. (2009) [89] | Massive trauma | Retrospective comparator | 134 (60 vs 74) | FFP:RBC ≥ 1:2 | FFP:RBC < 1:2 |
Sperry et al. (2008) [67] | Massive trauma | Retrospective comparator | 415 | FFP:RBC ≥ 1:1.5 | FFP:RBC < 1:1.5 |
Stinger et al. (2008) [90] | Massive trauma | Retrospective comparator | 252 | FFP high fibrinogen:RBC > 0.2 g fibrinogen/1 U RBC) | FFP low fibrinogen:RBC < 0.2 g fibrinogen/1 U RBC) |
Teixeira et al. (2009) [91] | Massive trauma | Retrospective comparator | 383 | FFP:RBC > 1:2 | FFP:RBC < 1:8, 1:8 to 1:3 and 1:3 to 1:2 |
Tomimaru et al. (2010) [92] | Surgery (hepatectomy for hepatocellular carcinoma) | Retrospective comparator | 497 (204 vs 293) | FFP median 10 U | No FFP (in 93% of patients in the group) |
Wright et al. (2008) [93] | CV surgery | Retrospective comparator | 211 (129 vs 82) | FFP (mixed donors) median 6 U | FFP (male-only donors) median 4 U |
Zink et al. (2009) [68] | Massive trauma | Retrospective comparator | 466 | FFP:RBC ≥ 1:1 | FFP:RBC < 1:1 |
Fibrinogen concentrate | |||||
Rahe-Meyer et al. (2009) [55] | CV surgery | Non RCT | 15 (10 vs 5) | Fibrinogen concentrate mean 5.7 g | FFP mean 4.2 U |
Rahe-Meyer et al. (2009) [26] | CV surgery | Prospective cohort vs historical control | 18 (6 vs 12) | Fibrinogen concentrate mean 7.2 g | FFP mean 9.1 U |