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Table 1 Summary details of eligible randomised, controlled trials

From: Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review

Study Indication Study type N patients (intervention group vs controls) Intervention details Control group
FFP
Boyd et al.
(1996) [108]
Surgery (renal transplantation; renal disease and coagulopathy) RCT 39 (19 vs 20) FFP 2 U Conjugated oestrogen 50 mg
Chong Sung
et al. (2006)
[35]
CV surgery (paediatric) RCT 42 (21 vs 21) FFP 10 ml/kg HES (130/0.4) 10 ml/kg
Consten et al.
(1996) [36]
CV surgery RCT 50 (24 vs 26) FFP 3 U Plasma substitute 3 U
Demeyere et al. (2010)
[37]
CV surgery in patients on OAT RCT 40 (20 vs 18) FFP 4 U (additional doses could be administered to reach target INR) PCC calculated to target INR of 1.5 (additional doses could be administered to reach target INR)
Etemadrezaie
et al. (2007)
[78]
Traumatic brain injury RCT 90 (44 vs 46) FFP 10 to 15 ml/kg Saline 10 to 15 ml/kg
Haubelt et al.
(2002) [38]
CV surgery Block-RCT 67 (31 vs 36) FFP 600 ml SD-FFP 600 ml
Kasper et al.
(2001) [41]
CV surgery RCT 56 (27 vs 29) FFP 15 ml/kg 6% HES (450/0.7) 15 ml/kg
Laine et al.
(2003) [64]
Liver transplantation RCT 33 (15 vs 18) FFP median 14 U (+10 U RBC) WB median 12 U
Menges et al.
(1992) [43]
Surgery (other) RCT 42 (16 vs 12/14) (Autologous) FFP + blood (dose not reported) Homologous RBC/autologous blood (dose not reported)
Mintz et al.
(2006) [65]
Liver transplantation RCT 51 (29 vs 22) FFP 22.7 U over 7 days PCT-FFP 21.3 U over 7 days
Noddeland et al. (2002)
[45]
CV surgery RCT 84 (55 vs 29) SD-FFP (2:1 Uniplas:Octaplas) median 3 U Uniplas:2 U Octaplas No FFP
Trimble et al.
(1964) [48]
CV surgery (adults, children) RCT 53 (21 vs 32) FFP 2 U adults, 1 U children No FFP
von Sommoggy
et al. (1990)
[49]
Surgery (other) RCT 24 (13 vs 11) FFP (+ human albumin) mean 2.7 U HES (dose not reported)
Wilhelmi et al.
(2001) [50]
CV surgery Block-RCT 120 (60 vs 60) FFP 4 U (1,000 ml) HES 1,000 ml
Williamson et al.
(1999) [22]
(duplicate data
in [21])
Surgery (liver) RCT 25 (13 vs 12) FFP median 44 ml/kg SD-FFP median 44 ml/kg
Fibrinogen concentrate
Cui et al.
(2010) [56]
CV surgery (children) RCT 31 (17 vs 14) Fibrinogen concentrate 0.5 to 1.0 g 'Standard allogeneic therapy'
Fenger-
Eriksen et al. (2009) [71]
Surgery (cystectomy) RCT 20 (10 vs 10) Fibrinogen concentrate 45 mg/kg Placebo (isotonic saline) 2.25 ml/kg
Karlsson et al.
(2009) [54]
CV surgery RCT 20 (10 vs 10) Fibrinogen concentrate 2 g No fibrinogen concentrate
  1. CV = cardiovascular; FFP = fresh frozen plasma; HES = hydroxyethyl starch; INR = International Normalised Ratio; OAT: oral anticoagulant therapy; PCT-FFP: photochemical treatment fresh frozen plasma; PCC: prothrombin complex concentrate; RBC: packed red blood cells; RCT = randomised, controlled trial; SD-FFP = solvent/detergent-treated fresh frozen plasma; WB = whole blood.