Table 2 Norepinephrine doses and hemodynamic variables
From: Effects of changes in arterial pressure on organ perfusion during septic shock
65 mm Hg | 75 mm Hg | 85 mm Hg | 65 mm Hg | |
|---|---|---|---|---|
Norepinephrine, μg/minute | 17.3 (5.9-28.6) | 24.5 (9.5-39.5)a | 32.7 (14.0-51.4)a | 22.4 (11.0-33.8) |
Mean arterial pressure, mm Hg | 66.0 (65.1-66.8) | 75.9 (73.5-78.3)a | 86.3 (84.3-88.4)a | 66.2 (65.1-67.3) |
Heart rate, beats per minute | 93.5 (83.9-103.1) | 91.4 (81.4-101.5) | 92.8 (82.1-103.6) | 94.2 (81.7-106.7) |
Cardiac output, liters per minute | 6.1 (5.4-6.8) | 6.5 (5.7-7.3) | 6.7 (5.9-7.6)a | 6.1 (5.4-6.8) |
Mean pulmonary arterial pressure, mm Hg | 29 (24.9-33.1) | 30.3 (26-34.7) | 32.2 (27.9-36.5)a | 29.4 (24.8-34.0) |
Pulmonary artery occlusion pressure, mm Hg | 15.3 (12.7-18) | 15.4 (12.7-18.2) | 16.1 (13.5-18.6) | 14.6 (12.2-17.1) |
Central venous pressure, mm Hg | 12.0 (9.8-14.3) | 12.8 (10.3-15.2) | 13.4 (11.1-15.7)a | 12.4 (10.3-14.5) |
Systemic vascular resistance, dyne/second per cm−5 | 716 (647-786) | 803 (711-896)a | 902 (793-1,010)a | 726 (645-806) |
Pulmonary vascular resistance, dyne/second per cm−5 | 181 (141-222) | 188 (141-234) | 197 (150-244) | 184 (134-234) |
Change in pulse pressure, percentage | 2 (1.5-4.5) | 2.5 (1-8) | 1.5 (0-4) | 4 (3-7) |