Changes of monocyte human leukocyte antigen-DR expression as a reliable predictor of mortality in severe sepsis

Table 2 Predictive value for 28-day mortality of ΔmHLA-DR and mHLA-DR

Number of patients	Variables	Cutoff value	Sensitivity	Specificity	Positive predictive value	Negative predictive value	AUC	95% CI	P value
72	ΔmHLA-DR₃	4.8%	89.0%	93.7%	70.9%	98.0%	0.919 ± 0.032	0.83-0.97	< 0.001
66	ΔmHLA-DR₇	9.0%	85.7%	90.0%	60.5%	97.2%	0.938 ± 0.030	0.851-0.982	< 0.001
66	ΔmHLA-DR_7-3	3.5%	66.1%	80.0%	37.1%	92.9%	0.729 ± 0.079	0.573-0.884	0.022
79	mHLA-DR₀	35.0%	89.1%	43.5%	62.1%	79.3%	0.570 ± 0.070	0.453-0.682	0.319
72	mHLA-DR₃	39.5%	91.1%	37.5%	54.6%	83.6%	0.629 ± 0.075	0.508-0.740	0.116
66	mHLA-DR₇	47.0%	94.6%	30.0%	49.8%	88.3%	0.598 ± 0.094	0.460-0.708	0.376

ΔmHLA-DR₃ and ΔmHLA-DR₇ were defined as the value change in mHLA-DR on days 3 and 7 compared with that on day 0, and ΔmHLA-DR_7-3 was defined as the value change in mHLA-DR on day 7 compared with that on day 3; mHLA-DR₀, mHLA-DR₃, and mHLA-DR₇ were defined as the value of mHLA-DR on days 0, 3, and 7. AUC, area under the curve; CI, confidence interval; mHLA-DR, monocyte human leukocyte antigen-DR.

ISSN: 1364-8535