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Table 2 Univariate and multivariate linear regression analyses of factors associated with sRAGE in diabetic and non-diabetics

From: sRAGE in diabetic and non-diabetic critically ill patients: effects of intensive insulin therapy

  Diabetic Non-diabetic
  Univariate Multivariate Univariate Multivariate
Variable Estimate P Estimate P Estimate P Estimate P
Age (years) -10.991 NS    -4.456 NS   
Gender 769.540 NS    88.840 NS   
BMI -4.315 NS    -42.630 NS   
APACHE II score 89.353 0.03 63.82 NS 28.739 NS   
SOFA score 186.919 NS    60.331 NS   
IL-6 (pg/ml) 3.479 0.01 1.22 NS 1.486 0.01 1.68 NS
Thrombomodulin (ng/ml) 4.165 NS    2.248 NS   
HMGB-1 (ng/ml) * -544.690 0.001 -509.97 0.002 -56.697 0.03 -49.56 0.059
Creatinine (μmol/l) 1.834 NS    2.658 0.005 1.58 NS
Creatinine clearance (ml/minute) -6.957 NS    -2.999 NS   
Blood glucose (mmol/L) -37.363 NS    -21.311 NS   
PaO2/FIO2 (mm Hg) 0.638 NS    1.066 NS   
INR 441.567 NS    16.071 NS   
  1. * P < 0.05 for both uni-and multivariate analysis
  2. APACHE, Acute Physiologic Score and Chronic Health Evaluation; BMI, body mass index; HMGB-1, high mobility group box-1; IL-6, interleukin-6; INR, international normalized ratio; PaO2/FIO2, ratio of partial pressure of oxygen to the fraction of inspired oxygen; SOFA, Sequential Organ Failure Assessment.