sRAGE in diabetic and non-diabetic critically ill patients: effects of intensive insulin therapy

Table 2 Univariate and multivariate linear regression analyses of factors associated with sRAGE in diabetic and non-diabetics

	Diabetic				Non-diabetic
	Univariate		Multivariate		Univariate		Multivariate
Variable	Estimate	P	Estimate	P	Estimate	P	Estimate	P
Age (years)	-10.991	NS			-4.456	NS
Gender	769.540	NS			88.840	NS
BMI	-4.315	NS			-42.630	NS
APACHE II score	89.353	0.03	63.82	NS	28.739	NS
SOFA score	186.919	NS			60.331	NS
IL-6 (pg/ml)	3.479	0.01	1.22	NS	1.486	0.01	1.68	NS
Thrombomodulin (ng/ml)	4.165	NS			2.248	NS
HMGB-1 (ng/ml) *	-544.690	0.001	-509.97	0.002	-56.697	0.03	-49.56	0.059
Creatinine (μmol/l)	1.834	NS			2.658	0.005	1.58	NS
Creatinine clearance (ml/minute)	-6.957	NS			-2.999	NS
Blood glucose (mmol/L)	-37.363	NS			-21.311	NS
PaO₂/FIO₂ (mm Hg)	0.638	NS			1.066	NS
INR	441.567	NS			16.071	NS

* P < 0.05 for both uni-and multivariate analysis
APACHE, Acute Physiologic Score and Chronic Health Evaluation; BMI, body mass index; HMGB-1, high mobility group box-1; IL-6, interleukin-6; INR, international normalized ratio; PaO₂/FIO_2, ratio of partial pressure of oxygen to the fraction of inspired oxygen; SOFA, Sequential Organ Failure Assessment.

ISSN: 1364-8535